原创力文档the pleiotropic cymr regulator of staphylococcus aureus plays an important role in virulence and stress response多效cymr调节器的金黄色葡萄球菌中扮演一个重要的角色在毒性和应激反应.pdfVIP
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the pleiotropic cymr regulator of staphylococcus aureus plays an important role in virulence and stress response多效cymr调节器的金黄色葡萄球菌中扮演一个重要的角色在毒性和应激反应
The Pleiotropic CymR Regulator of Staphylococcus
aureus Plays an Important Role in Virulence and Stress
Response
1 ¤ 2 2 2 1¤
Olga Soutourina * , Sarah Dubrac , Olivier Poupel , Tarek Msadek , Isabelle Martin-Verstraete
´ ´ ´ ´ ´ ´ ´ ` `
1 Institut Pasteur, Unite de Genetique des Genomes Bacteriens, CNRS URA 2171, Paris, France, 2 Institut Pasteur, Unite de Biologie des Bacteries Pathogenes a Gram Positif,
CNRS URA 2172, Paris, France
Abstract
We have characterized a novel pleiotropic role for CymR, the master regulator of cysteine metabolism. We show here that
CymR plays an important role both in stress response and virulence of Staphylococcus aureus. Genes involved in
detoxification processes, including oxidative stress response and metal ion homeostasis, were differentially expressed in a
DcymR mutant. Deletion of cymR resulted in increased sensitivity to hydrogen peroxide-, disulfide-, tellurite- and copper-
induced stresses. Estimation of metabolite pools suggests that this heightened sensitivity could be the result of profound
metabolic changes in the DcymR mutant, with an increase in the intracellular cysteine pool and hydrogen sulfide formation.
Since resistance to oxidative stress within the host organism is important for pathogen survival, we investigated the role of
CymR during the infectious process. Our results indicate that the deletion of cymR promotes survival of S. aureus inside
macrophages, whereas virulence of the DcymR mutant is highly impaired in mice. These data indicate that CymR plays a
major role in virulence and ada
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