原创力文档the relation between cartilage biomarkers (c2c, c1,2c, cs846, and cpii) and the long-term outcome of rheumatoid arthritis patients within the camera trial软骨生物标志物的关系(c2c、c1、2 c,cs846 cpii)和相机内的风湿性关节炎患者的长期预后审判.pdfVIP
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the relation between cartilage biomarkers (c2c, c1,2c, cs846, and cpii) and the long-term outcome of rheumatoid arthritis patients within the camera trial软骨生物标志物的关系(c2c、c1、2 c,cs846 cpii)和相机内的风湿性关节炎患者的长期预后审判
Bakker et al. Arthritis Research Therapy 2011, 13:R70
/content/13/3/R70
RESEARCH ARTICLE Open Access
The relation between cartilage biomarkers (C2C,
C1,2C, CS846, and CPII) and the long-term
outcome of rheumatoid arthritis patients within
the CAMERA trial
1* 1 1,2 1 3
Marije F Bakker , Suzanne MM Verstappen , Paco MJ Welsing , Johannes WG Jacobs , Zalima N Jahangier ,
4 1 1
Maaike J van der Veen , Johannes WJ Bijlsma and Floris PJG Lafeber for
the Utrecht Arthritis Cohort study group
Abstract
Introduction: The aim of this study was to investigate whether serum biomarker levels of C2C, C1,2C, CS846, and
CPII can predict the long-term course of disease activity and radiographic progression early in the disease course
of rheumatoid arthritis (RA).
Methods: In patients in the CAMERA trial, levels of biomarkers were evaluated at baseline and after 1 year of
treatment. Relations of (changes in) biomarker values with the mean yearly radiographic progression rate and
mean disease activity over a 5-year period were evaluated by using regression analysis. The added predictive value
of biomarkers over established predictors for long-term outcome was analyzed by multiple linear regression
analysis.
Results: Of 133 patients, serum samples were available at baseline and after 1 year of treatment. In the regression
analysis C1,2C at baseline, the change in C2C, C1,2C, and the sum of the standardized changes in C2C + C1,2C
scores were statistically significantly associated with the mean yearly radiographic progression rate; the change in
CPII was associated with the mean disease activity
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