the role of human t-lymphocyte-monocyte contact in inflammation and tissue destruction人类的角色t-lymphocyte-monocyte联系在炎症和组织破坏.pdfVIP

Available online /content/4/S3/S169 Supplement Review The role of human T-lymphocyte–monocyte contact in inflammation and tissue destruction Danielle Burger and Jean-Michel Dayer Division of Immunology and Allergy, Clinical Immunology Unit, University Hospital, Geneva, Switzerland Correspondence: Dr D Burger, Clinical Immunology Unit, University Hospital, 24 rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland. Tel: +41 22 372 9376; fax: +41 22 372 9369; e-mail: danielle.burger@hcuge.ch Received: 28 February 2002 Arthritis Res 2002, 4 (suppl 3):S169-S176 Revisions requested: 1 March 2002 This article may contain supplementary data which can only be found Revisions received: 4 March 2002 online at /content/4/S3/S169 Accepted: 7 March 2002 © 2002 BioMed Central Ltd Published: 9 May 2002 (Print ISSN 1465-9905; Online ISSN 1465-9913) Chapter summary Contact-mediated signaling of monocytes by human stimulated T lymphocytes (T ) is a potent L proinflammatory mechanism that triggers massive upregulation of the proinflammatory cytokines IL-1 and tumor necrosis factor-α. These two cytokines play an important part in chronic destructive diseases, including rheumatoid arthritis. To date this cell–cell contact appears to be a major endogenous mechanism to display such an activity in monocyte-m