the role of innate apobec3g and adaptive aid immune responses in hla-hivsiv immunized shiv infected macaques先天apobec3g和自适应的角色帮助免疫反应hla-hivsiv免疫shiv感染的猕猴.pdfVIP

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the role of innate apobec3g and adaptive aid immune responses in hla-hivsiv immunized shiv infected macaques先天apobec3g和自适应的角色帮助免疫反应hla-hivsiv免疫shiv感染的猕猴.pdf

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the role of innate apobec3g and adaptive aid immune responses in hla-hivsiv immunized shiv infected macaques先天apobec3g和自适应的角色帮助免疫反应hla-hivsiv免疫shiv感染的猕猴

The Role of Innate APOBEC3G and Adaptive AID Immune Responses in HLA-HIV/SIV Immunized SHIV Infected Macaques 1 1 1 3 2 Yufei Wang , Trevor Whittall , Durdana Rahman , Evelien M. Bunnik , Robert Vaughan , 4 5 6 7 3 Jørgen Schøller , Lesley A. Bergmeier , David Montefiori , Mahavir Singh , Hanneke Schuitemaker , Thomas Lehner1* 1 Mucosal Immunology Unit, King’s College London, Guy’s Hospital, London, United Kingdom, 2 Department of Tissue Typing, King’s College London, Guy’s Hospital, London, United Kingdom, 3 AMC Medical Research, Amsterdam, The Netherlands, 4 Immudex, Copenhagen, Denmark, 5 Queen Mary, University of London, Barts and The London Schools of Medicine and Dentistry, Centre for Clinical and Diagnostic Oral Sciences, London, United Kingdom, 6 Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America, 7 Lionex GmbH, Braunschweig, Germany Abstract The AID/APOBEC family (activation induced deaminase/apolipoprotein B mRNA editing cytokine deaminase) in B cells play important roles in adaptive and innate immunity. Whereas APOBEC3G has been studied in CD4+ T cells and myeloid cells its functional potential in B cells has received little attention. AID combines two critical functions of antibodies, class switching and affinity maturation and may serve as a functional surrogate of protection. These functions were studied following systemic immunization of rhesus macaques with recombinant HLA constructs, linked with HIV and SIV antigens and HSP70 to dextran. The results showed significant upregulation of AID in CD20+ B cells, APOBEC 3G in CD27+ memory B cells and CD