原创力文档the sfp-type 4′-phosphopantetheinyl transferase ppt1 of fusarium fujikuroi controls development, secondary metabolism and pathogenicity镰fujikuroi sfp-type 4u2032-phosphopantetheinyl转移酶ppt1控件开发、次生代谢和致病性.pdfVIP
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the sfp-type 4′-phosphopantetheinyl transferase ppt1 of fusarium fujikuroi controls development, secondary metabolism and pathogenicity镰fujikuroi sfp-type 4u2032-phosphopantetheinyl转移酶ppt1控件开发、次生代谢和致病性
The Sfp-Type 4 9-Phosphopantetheinyl Transferase Ppt1
of Fusarium fujikuroi Controls Development, Secondary
Metabolism and Pathogenicity
1 1 1 1,2 2
Philipp Wiemann , Sabine Albermann , Eva-Maria Niehaus , Lena Studt , Katharina W. von Bargen ,
3 2 3 1
Nelson L. Brock , Hans-Ulrich Humpf , Jeroen S. Dickschat , Bettina Tudzynski *
¨ ¨ ¨ ¨ ¨ ¨
1 Institut fur Biologie und Biotechnologie der Pflanzen, Westfalische Wilhelms-Universitat Munster, Hindenburgplatz 55, Munster, Germany, 2 Institut fur
¨ ¨ ¨ ¨ ¨ ¨
Lebensmittelchemie, Westfalische Wilhelms-Universitat Munster, Corrensstraße 45, Munster, Germany, 3 Institut fur Organische Chemie, Technische Universitat
Braunschweig, Hagenring 30, Braunschweig, Germany
Abstract
The heterothallic ascomycete Fusarium fujikuroi is a notorious rice pathogen causing super-elongation of plants due to the
production of terpene-derived gibberellic acids (GAs) that function as natural plant hormones. Additionally, F. fujikuroi is
able to produce a variety of polyketide- and non-ribosomal peptide-derived metabolites such as bikaverins, fusarubins and
fusarins as well as metabolites from yet unidentified biosynthetic pathways, e.g. moniliformin. The key enzymes needed for
their production belong to the family of polyketide synthases (PKSs) a
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