the sexually antagonistic genes of drosophila melanogaster黑腹果蝇的基因性对抗.pdfVIP

The Sexually Antagonistic Genes of Drosophila melanogaster Paolo Innocenti*, Edward H. Morrow Department of Animal Ecology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden Abstract When selective pressures differ between males and females, the genes experiencing these conflicting evolutionary forces are said to be sexually antagonistic. Although the phenotypic effect of these genes has been documented in both wild and laboratory populations, their identity, number, and location remains unknown. Here, by combining data on sex-specific fitness and genome-wide transcript abundance in a quantitative genetic framework, we identified a group of candidate genes experiencing sexually antagonistic selection in the adult, which correspond to 8% of Drosophila melanogaster genes. As predicted, the X chromosome is enriched for these genes, but surprisingly they represent only a small proportion of the total number of sex-biased transcripts, indicating that the latter is a poor predictor of sexual antagonism. Furthermore, the majority of genes whose expression profiles showed a significant relationship with either male or female adult fitness are also sexually antagonistic. These results provide a first insight into the genetic basis of intralocus sexual conflict and indicate that genetic variation for fitness is dominated and maintained by sexual antagonism, potentially neutralizing any indirect genetic benefits of sexual selection. Citation: Innocenti P, Morrow EH (2010) The Sexually Antagonistic Genes of Drosophila melanogaster. PLoS Biol 8(3): e1000335. doi:10.1371/journal.pbio.1000335 Academic Editor: Laurence D. Hurst, University of Bath, United Kingdom Received December 8, 2009; Accepted February 10, 2010; Published March 16, 2010 Copyright: 2010 Innocenti, Morrow. This is an open-access article distributed under the terms of the Creative Common