the similarity of gene expression between human and mouse tissues相似的基因表达在人类和小鼠组织之间.pdfVIP

Dowell Genome Biology 2011, 12:101 /2011/12/1/101 R E S E A R C H H I G H L I G H T The similarity of gene expression between human and mouse tissues Robin D Dowell* See research article: /2010/11/12/R124 and organism status (such as age and sex). ese tech- Abstract nical difficulties effectively stack the deck against finding Meta-analysis of human and mouse microarray data conservation, and often lead to overestimation of differ- reveals conservation of patterns of gene expression ences in gene expression between species. Effective that will help to better characterize the evolution of cross-species comparison, therefore, requires these tech- gene expression. nical challenges to be addressed [3]. Mouse models are crucial in biomedical research, so understanding the differences and similarities between e phenotype of an animal cell originates from a mouse and human is of fundamental importance. Conse- combination of its gene content and the regulation of quently, tremendous attention has been paid to the those genes. In general, vertebrates have roughly equiva- comparison of human and mouse expression profiles. lent numbers of genes, so differences in gene regulation Early comparisons indicated that the expression profiles of are postulated to explain the vast amount of phenotypic orthologous genes differ substantively bet