原创力文档the thioredoxin trx-1 modulates the function of the insulin-like neuropeptide daf-28 during dauer formation in caenorhabditis elegans的硫氧还蛋白trx-1调节胰岛素样的功能神经肽daf-28多尔形成中线虫.pdfVIP
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the thioredoxin trx-1 modulates the function of the insulin-like neuropeptide daf-28 during dauer formation in caenorhabditis elegans的硫氧还蛋白trx-1调节胰岛素样的功能神经肽daf-28多尔形成中线虫
The Thioredoxin TRX-1 Modulates the Function of the
Insulin-Like Neuropeptide DAF-28 during Dauer
Formation in Caenorhabditis elegans
´ 1 2 2 3,4 .
Juan Carlos Fierro-Gonzalez , Astrid Cornils , Joy Alcedo , Antonio Miranda-Vizuete * , Peter
1 .
Swoboda *
1 Department of Biosciences and Nutrition, Center for Biosciences at NOVUM, Karolinska Institute, Huddinge, Sweden, 2 Friedrich Miescher Institute for Biomedical
´ ´ ´ ´
Research, Basel, Switzerland, 3 Departamento de Fisiologıa, Anatomıa y Biologıa Celular, Centro Andaluz de Biologıa del Desarrollo - Consejo Superior de Investigaciones
´ ´
Cientıficas (CABD-CSIC), Universidad Pablo de Olavide, Sevilla, Spain, 4 Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocıo, Consejo Superior de
´
Investigaciones Cientıficas, Universidad de Sevilla, Sevilla, Spain
Abstract
Thioredoxins comprise a conserved family of redox regulators involved in many biological processes, including stress
resistance and aging. We report that the C. elegans thioredoxin TRX-1 acts in ASJ head sensory neurons as a novel
modulator of the insulin-like neuropeptide DAF-28 during dauer formation. We show that increased formation of stress-
resistant, long-lived dauer larvae in mutants for the gene encoding the insulin-like neuropeptide DAF-28 requires TRX-1
acting in ASJ neurons, upstream of the insulin-like recepto
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