泌尿生殖道支原体耐药性分析.docVIP

泌尿生殖道支原体耐药性分析 　【摘要】 目的：了解解脲脲原体（Uu）、人型支原体（Mh）在泌尿生殖道的感染状态及耐药状况。方法：对疑似患者送检的2 623份标本进行Uu、Mh培养及药物敏感性测试，对Uu、Mh检出阳性率及对12种抗生素的耐药性做统计分析。结果：在本研究中，在2 623份标本中支原体检出总阳性率为34.4%，仅检出Uu或Mh的标本阳性率分别为32.7%、1.0%，同时检出Uu和Mh的标本阳性率为1.0%。生殖道支原体感染中以Uu感染为主，占95.2%。支原体感染率女性明显高于男性（Plt;0.01）。对12种抗生素的耐药率分别从16.3%～71.6%不等。结论：Uu是泌尿生殖道支原体感染的主要病原体，Uu对红霉素的耐药率最高，对交沙霉素、克拉霉素、强力霉素、环脂红霉素敏感性较好，可作为治疗Uu感染的首选药物，但Mh的耐药性与Uu的耐药性很不一样，其耐药性要较Uu严重。 【关键词】 泌尿生殖道；支原体；耐药性 　　Analysis of Drug Resistance of Mycoplasmain in Genitourinary Tract Abstract: Objective To recognize the infection status of Ureaplasma urealyticum(Uu) and Mycoplasma hominis(Mh) and the drug resistance in genitourinary tract. Methods Uu and Mh was identified and the susceptibility for 12 antibiotics was detected in 2 623 samples ,and then analyze the positive percentage and the drug resistance. Results In the study ,from 2 623 samples ,the total positive percentage for Mycoplasma was 34.4% ,the isolation percentage of Uu and Mh was 32.7% and 1.0% respectively，and 0.7% samples were isolated Uu except Mh．Uu was much more than Mh from samples，the percentage of Uu was 95.2% in the total pathogen．The positive percentage from female samples was higher than that from male samples (Plt;0.01）．The drug resistance percentage of Mycoplasma was from 16.3% to 71.6% respectively．Conclusion Uu was the primary pathogen in genitourinary tract infection with Mycoplasma． The resistance to Erythromycin of Uu was the most highest，but the sensitivity to Josanmycin，Clarithromycin，Doxycycline，Davercin was high，they may be as the primary drugs to treat genitourinary tract infection with Uu．The drug resistance of Mh was different from that of Uu and more significant． Key words: Genitourinary tract；Mycoplasma； Drug resistance 解脲脲原体（Uu）、人型支原体（Mh）是引起非淋菌性尿道炎（NGC）、泌尿生殖道炎症的主要病原体之一，还可引起前列腺炎、宫颈炎、盆腔炎、不孕不育甚至流产等。尽管药物敏感性报告能为这类感染的治疗提供很好的用药依据，但临床上仍存在有经验用药的情况，为了了解本地区Uu、Mh的耐药状况，本研究对泌尿生殖道中的Uu、Mh分离情况及耐药性做一分析。 　　1 材料和方法 　　1.1 标本来源 　　2006年6月至2007年6月来本院皮肤科门诊、妇科门诊及泌尿外科门诊就诊的疑似UU、MH感染的泌尿生殖道炎症患者2 623例，