美托康对突发性耳聋患者听力恢复影响.docVIP

美托康对突发性耳聋患者听力恢复影响 　【摘要】 目的：探讨美托康(杏芎氯化钠注射液)对突发性耳聋患者听力恢复的影响,并对其疗效及安全性进行评价。方法：65例突发性耳聋患者随机分为两组，对照组31例，给予低分子右旋糖苷注射液作为常规治疗；治疗组在与对照组相同治疗的基础上加用美托康250 ml静脉滴注，1次/d，共10 d。观察两组病例治疗后听力的恢复情况。结果：治疗组总显效率83.3%,对照组总显效率63.6%,两组比较差异有显著性(Plt;0.05)。未见严重的不良反应和并发症。结论：美托康通过扩张血管、改善血液流变学,提高疾患器官的血供,对突发性耳聋患者的听力的恢复有显著作用。 【关键词】 美托康(杏芎氯化钠注射液)；突发性耳聋；听力恢复 　　The Effcct of Maitork on the Auditory Recovery of the Patients with Sudden Deaffines 　　Abstract:Objective To observetheeffect of Maitork (Xingxiong sodium chloride injection) on the auditory recovery ofthe patients with sudden deaffines.Methods 65 sudden deaffines patients were divided into two groups according to singleblind random method,34 cases in in treating group and 31 in the control group.Patients in the control group were treated by dextran40 500 ml injection (ivgtt，qd),and treating group were treated by Maitork 250 ml(ivgtt，qd) in addition，all the patients were treated 10 days.Object the auditory recovery of the patient with suddent deaffines.Results The total effective rate of the treated group was 83.3%,that of the control group was 63.6%,and statistic analysis showed that the difference ofthe total effective rate was significant between two groups (P＜0.05),and treating group was better than the control group,no harmful reaction s and complication were found in treatment group.Conclusion Maitork has curative effect onthe the auditory recovery ofpatients with sudden deaffines.It can dilatate vessels,improve hemorrheololgy andadvance the blood supply. 　　Key words:Maitork(Xingxiong sodium chloride injection);The patients with sudden deaffines；The auditory recaery 　　美托康(杏芎氯化钠注射液)是由银杏叶提取物和磷酸川芎嗪组成的复方制剂。它具有改善微循环，促进侧支循环建立，协同抑制自由基损伤，保护神经细胞和协同抗血栓的作用，已经广泛应用于心脑血管疾病的治疗，应用于突发性耳聋的治疗尚未见报道，我科于2005年3月至2006年8月，应用美托康治疗突发性耳聋患者，并观察其对听力恢复有明显疗效，现报告如下。 　　1 资料与方法 　　1.1 临床资料 65例患者均按照中华医学会耳鼻咽喉科学会、中华耳鼻咽喉科杂志编辑委员会1996年上海会议制定的诊断标准［1］诊断为突发性耳聋,并随机分为两组:治疗组34例(36耳)男15例,女19例;年龄16岁～77岁,其中41岁～50岁共15例,为最多。纯音测听、阻抗测听、听觉脑干诱发电位测试显示为感音神经性聋。6个频率(250 Hz、500 Hz、1 000 Hz、2 000 Hz