异源蛋白质相互作用数据整合算法的进展.PDF

20 5 Vol. 20, No. 5 2008 10 Chinese Bulletin of Life Sciences Oct., 2008 1004-0374(2008)05-0821-06 1 200444 2 200031 : k - Q5 1 Q811 .4 Q81 6 A Advances in algorithms applied on various protein-protein interaction data sources integration 1 1 2 WANG Wen-xin , CHEN Yu-guang , SHI Tie-liu * (1School of Life Sciences, Shanghai University, Shanghai 200444, China; 2Shanghai Information Center for Life Sciences, Chinese Academy of Sciences, Shanghai 200031, China) Abstract: Protein-protein interactions are crucial for all biological processes and fundamental to virtually every aspect of cellular functions. Developments of high through-put experimental techniques and in silico prediction methods help to increase direct and indirect protein-protein interactions data. How to systematically integrate those data and extract the meaningful information from them is a really challenge. Many computational ap- proaches are therefore emerging for the purposes. This review presents recent advances for the application of those approaches in integrating protein-protein interaction data sources, including voting, support vector machine, naive bayes, logistic regression, decision tree, random forest (RF), RF-based k-nearest-neighbor and mixture of feature experts. Key words: protein-protein interaction; data integration; binary classifier