抗生素封管预防血透患者临时中心静脉留置导管相关感染的研究.pdfVIP

1112 Journal of Qiqihar M edi al College, 2008, Vol. 29, No. 9 抗生素封管预防血透患者临时中心静脉留置导管 相关感染的研究 刘仕艳 汤 颖 李荣英 ! 评价抗生素封管对中心静脉留置导管相关感染的预防作 , 探讨感染控制的有效 措施 选择113 例临时中心静脉留置导管的血透患者, 随机分为两组: 对照组 53 例采 单纯肝 素封管( 肝素组) ; 实验组60 例采 肝素+ 头孢唑啉联合封管( 抗生素组) 随访两组导管相关感染的发 病率并使 卡方检验进行比较同时将肝素组和本血透中心既往中心静脉导管相关性感染的发病率进 行比较 感染共7 例次, 总体感染发病率为6. 19% , 其中肝素组 3 例次, 感染发病率为 5. 66% , 抗生素组4 例次, 感染发病率为6. 67% , 两组的发病率无显著性差别( P 0. 05) 肝素组和既往中心静 脉导管相关性感染的发病率( 17. 94% ) 有显著差异( P 0. 05) 加 头孢唑啉封管对中心静脉 留置导管相关感染的发病无明显预防作 ; 严格无菌操作和加强护理是降低感染减少抗生素使 的关 键措施 ! 抗生素封管 导管相关感染 中心静脉留置导管 血液透析 Use of an antimicrobial lock solution for prevention of the catheter related infections in hemodialysis patients with temporary central vein catheter LI U Sh i - y an, et al . ( Department of Blood purifi ation, Zhongshan H ospital, Fudan U niversit y, Shanghui 200032 P. R. China) Abstract! Objective T o identify the effi a y of antimi robial solut ion for preventing the at heter relat ed infe tions in hemodilysis patients w ith temporary entral vein atheter and sear h for the better ont rol methods. Methods One hundred- thirteen patients w ith new temporary hemodialy sis athet ers were enrolled into the study , and w ere randomly assigned to re eive either heparin lo k solution ( heparin 50mg/ ml) or antim i robial lo k solution ( efazolin 10mg/ ml, heparin45mg/ ml) , patients w ere followed up. Data analy sis w as performed with 2- tailed Fisherexa t test, meanw hile, the previous atheter relat ed infe t ion in iden e w as ontrasted w ith the heparin group. Results Seven pat ient s developed infe t ions. T otal infe tion in iden e w as 6. 19% . t here of fifty- t hree patients in the heparin group( 5. 66% ) , four of sixt y patients in the efazolin group( 6. 67% ) , no signifi ant differen es (P 0