维生素d抗结直肠癌的研究进展-tumor.pdfVIP

1064 　　肿瘤2014 年11 月第34 卷第11 期　TUM OR Vol. 34, November 2014 DOI: 10.3781/j .issn.1000-7431.2014.55.252 Copyright© 2014 by TUM OR Review 综述 · 维生素D抗结直肠癌的研究进展 1, 2 2 2 方　莹 ，宋皓军 ，丁小云 1. 宁波大学医学院研究生院，浙江宁波　3152 11；2 . 浙江省宁波市第一医院消化内科，浙江宁波　315010 [摘要]　结直肠癌是一种常见的恶性肿瘤，其发病机制涉及多个方面。目前流行病学及基础研究均支持，维 生素D 缺乏可能是导致结直肠癌的危险因素之一。进一步研究显示，维生素D 与维生素D 受体结合后可调节 c -my c 、抗凋亡因子B 细胞性淋巴瘤-2 （B cell lymphoma-2 ，Bcl -2 ）、表皮生长因子受体 （epidermal growth factor receptor ，EGFR ）和血管内皮生长因子 （vascular endothelial growth factor ，VEGF ）等与肿瘤分化、增殖、凋亡 及血管形成相关的基因，从而发挥抗结直肠癌的作用。此外，维生素D 还可通过调节Wnt 、表皮生长因子（epidermal growth factor ，EGF ）和转化生长因子-β （transforming growth factor-β，TGF-β ）等信号通路来拮抗结直肠癌。因此， 本文将对维生素D 抗结直肠癌相关的研究现况作一综述，以期为结直肠癌的防治提供一些新的线索。 [关键词]　结直肠肿瘤；维生素D ；受体，维生素D ；信号转导 [中图分类号]　R735.34 [文献标志码] A [文章编号]　1000-7431 (2014) 11-1064-05 Advances in anti-cancer effect of vitamin D on colorectal cancer 1, 2 2 2 FANG Ying , SONG Hao-jun , DING Xiao-yun 1. Graduate School, Medical College, Ningbo University, Ningbo 315211, Zhejiang Province, China; 2. Department of Gastroenterology, Ningbo First Hospital, Ningbo 315010, Zhejiang Province, China [A BSTRACT]　Colorectal cancer is a kind of common malignant cancer, and its pathogenesis involves in several aspects. Recent epidemiological and experimental studies both support that vitamin D deficiency may be a risk factor for colorectal cancer. Further research have shown that vitamin D binding to its receptor can inhibit the cancer by regulating many genes involved in tumor differentiation, cell proliferation, apoptosis, and vascular formation, such as c -myc , B cell lymphoma-2 (Bcl-2), epidermal growth factor receptor (EGFR) and vascular