PINK1在黏液性上皮性卵巢肿瘤中表达的研究.pdfVIP

见代肿瘤医学 2014年 2月 第 22卷第 2期 MODERNONCOLOGY，Feb20[4，VOL．22，NO 02 ·393 PINK1在黏液性上皮性卵巢肿瘤中表达的研究 刘 川 ，王华芹 ，王慧敏 ，胡珍华 ，英焕春 ，林 蓓 ExpressionofPINK1inovarianmucinousfumOs『 LiuChuan ，WangHuaqin ，WangHuimin ，HuZhenhua ，YingHuamhun ，LinBei Department Obstetricsand necology，ShengfingHospitalAffdiatedtoChinaMedicalUniversity，LiaoningShenyang110004，Chi ；Department BiochemistryandMolecularBiology，ChinaMedicalUniversity，LiaoningShenyang 110001，China 【Abstract】 Objective：ToinvestigatetheexpressionofPINK1inovariannlucinoustunlorsandtherelationshipsbe— tweenPINK1andtheclinicalpathological paranletersin malignantovarian nlucinoustumorsM ethods：SP nlethod wasusedtodetectthepositiveexpressionratesofPINK1in58casesofovarianIllUSiOnstmnorsand15casesofnor— lnalovariantissues，andtherelationshipbetweentheexpressionofPINK1andtheclinicalpathologicalparanleters(FI— GOstages，histologicalgrades，lymphaticmetastasis)inmalignantovarianlllucinoustumorswasanalyzedResults： ThepositiveratesofPINK1inmalignantandborderlinenlucioustmnorswere9643％ ．62 5％ ．therewasstatistical significancebetweenthem，andbothofthenlwereevidentlyhigherthanthoseinbenigntmnors(1429％)andnorlnal tissues(1333％)，Kruskal—WallisHTestdemonstratedthestatisticalsignificantdifferenceinthefourgroups(P 00001)TherewasnostatisticaldifferencebetweentheexpressionofPINK1andtheclinicalpathologicalparanle— ters(FIGOstages，histologicalgrades，lylnphaticmetastasis)inmalignantovarianlllucinoustumors，Pvalueswere 0 243、0 483、0 144 Conclusion：PINK1participatesintheprocedureofmalignanttransformationofbenignnlucious ovariantmnors，andthexepressionofPINK1hasnocorrelationwithFIGO stage，differentiationandlylnphaticlnetasta— slsoflnalignantovarian nlHcin0HStulnors 【Keywords】ovariannlHcin0HStunlor；PINK1；… un0hlst0ch sry ModernOncology2014，22(02)：0393—0396