芍甘颗粒提取、精制工艺线路设计.docVIP

目 录 1. 设计任书···················································03 2. 设计概述···················································04 2.1处方··················································04 2.2 用法··················································04 2.3功能主治···············································04 2.4药理作用···············································04 2.5颗粒剂介绍·············································05 3.常用精制技术简介············································06 3.1 常用精制分离方法······································06 3.2简析···················································06 4.课程实验····················································08 5.工艺路线设计················································15 5.1 处方···················································15 5.2制备工艺···············································15 5.3工艺流程及工艺说明·····································16 5.3.1工艺流程···········································16 5.3.2 工艺说明···········································17 5.4提取物生产过程数据表····································18 6. 结束语·····················································19 7. 参考文献···················································19 设计任务书 一、设计题目 芍甘汤提取、精制工艺设计 【来源】本品为毛茛科植物芍药Paeonia lactiflora Pall.的干燥根。夏、秋二季采挖，洗净，除去头尾和细根，置沸水中煮后除去外皮或去皮后再煮，晒干。 【药性】苦、酸，微寒。归肝、脾经。 【功效】养血调经，敛阴止汗，柔肝止痛，平抑肝阳。 【主治】用于血虚萎黄，月经不调，自汗，盗汗，胁痛，腹痛，四肢挛痛，头痛眩晕。 甘草 【来源】本品为豆科植物甘草Glycyrrhiza uralensis Fisch.、胀果甘草Glycyrrhiza inflata Bat.或光果甘草Glycyrrhiza glabra L.的干燥根和根茎。春、秋二季采挖，除去须根，晒干。 【药性】甘，平。归心、肺、脾、胃经。 【功效】补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。 【主治】用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。 2、用法 取上述2味，加600mL水煎煮至300mL，取液去渣，温服。 3、功能主治 本方主治津液受损，阴血不足，筋脉失濡所致诸证。方中芍药酸寒，养血敛阴，柔肝止痛；甘草甘温，健脾益气，缓急止痛。二药相伍，酸甘化阴，调和肝脾，有柔筋止痛之效。 其中芍药对疼痛中枢和脊髓性反射弓的兴奋有镇静作用，故能治疗中枢性或末梢性的筋系挛急，以及因挛急而引起的疼痛。芍药、甘草中的成分有镇静、镇痛、解热、抗炎、松弛平滑肌的作用，二药合用后，这些作用确能显著增强。–吸收快、显效迅速 (克服前体剂型的不足); –方便 –稳定 –口感好 缺点: –成本高 –易潮解 –对包装方法和材料要求高 –机动性差 –无法随证加减;适口性稍差(与包衣剂相比) 常用精制技术简介 1、常用精制分离方法 （1）根据物质溶解度差别进行分离： 结晶及重结晶法、沉淀法（水提醇沉