鼠神经生长因子对急性脑梗死患者血清超敏—C反应蛋白与神经元特异性烯醇化酶水平影响和疗效观察.docVIP

鼠神经生长因子对急性脑梗死患者血清超敏—C反应蛋白与神经元特异性烯醇化酶水平影响和疗效观察 　　[摘要] 目的 探讨鼠神经生长因子对急性脑梗死患者血清超敏-C反应蛋白（hs-CRP）和神经元特异性烯醇化酶（NSE）水平的影响及疗效观察。方法 72例急性脑梗死患者随机分为观察组和对照组。两组均予以控制颅内压、血压和血糖、抗血小板聚集、保护脑细胞及防治并发症等治疗。观察组患者加用鼠神经生长因子18 μg肌肉注射，1次/d，连用2周。结果 治疗2周后，两组患者血清hs-CRP和NSE水平均有明显下降（P0.05）。 结论 鼠神经生长因子治疗急性脑梗死具有较好的疗效及安全性，能明显改善患者的神经功能及肢体运动功能，作用与其能降低血清Nhs-CRP和NSE水平密切相关。 [关键词] 急性脑梗死；鼠神经生长因子；超敏-C反应蛋白；神经元特异性烯醇化酶 [中图分类号] R743 [文献标识码] B [文章编号] 1673-9701（2014）02-0030-03 The influence and curative effect of mouse nerve growth factor on high-sensitivity C-reactive protein（hs-CRP） and neuron-specific enolase （NSE） in blood serum of acute cerebral infarction patients WEI Ying LI Haijun No.2 Department of Nerve， Taizhou Municipal Hospital， Zhejiang （The Affiliated Municipal Hospital of Taizhou Medical College）， Taizhou 318000，China [Abstract] Objective To discuss the influence and curative effect of mouse nerve growth factor on high-sensitivity C-reactive protein（hs-CRP） and neuron-specific enolase （NSE） in blood serum of acute cerebral infarction patients. Methods 72 cases of acute cerebral infarction patients were divided into observation group and control group. All patients were given symptomatic and supportive treatment routinely like，intracranial pressure control， blood pressure and blood sugar control， platelet aggregation， brain cells protection， prevention and treatment of complications，and etc. The patients in observation group were given mouse nerve growth factor（18 μg） by intramuscular injection one time daily for 2 weeks. Results After 2 weeks medical treatment，the serum hs-CRP and NSE levels of patients in two groups obviously were declined than before （P0.05）. Conclusion Mouse nerve growth factor has good clinical curative effect on acute cerebral infarction with security，and can obviously improve the function of nerve and body movement of patients，whose mechanism of action has close effect on reducing the serum hs-CRP and NSE levels. 　　[Key words] Acute cerebral infarction； Mous