嗜热链球菌grx02对酒精性肝损伤大鼠保护作用的分子机制 study on the protection molecular mechanism of streptococcus thermophilus grx02 on the alcoholic liver injury in rats.pdfVIP

q^Ⅳw．chimdairy．net 中国乳品工业 zgrpgy@163．com 嗜热链球菌grx02对酒精性肝损伤大鼠保护作用 的分子机制 黄玉军’陈蠢2，顾瑞震j栾少萌：王慧昌j孙云“ (扬州大学a．扭苏孔品生物技术与安全控制重点实验室．b．医学院，江苏扬州225127) 摘要：研究了嗜热链球菌grx02对急性酒精性肝损伤大鼠模型的保护作用机制。建立了怠性酒精性肝损伤大鼠模型，观察嗜热链球菌 肚!(02对急性酒精性肝损伤大鼠血清转氨酶以及炎症细胞因子的改善作用。结果表明．酒精可谤导大鼠血清谷氨酸氨基转移酶(ALT)、天 肝损伤．对大鼠急性酒精性肝损伤发挥保护作用。 关键词：嗜热链球茼grx02；急性酒精性肝损伤；氧化应激；肿瘤坏兄因子一位；Ⅱ，-邶；IL一8 中图分类号：Q93—33 文献标识码：A 文章编号：1001～223012012】06-0004一04 011the molecularmechanismof Study protection StreptococcusThermophilusgrx02 ontheAlcoholicLiver inRats Injury HUANG xia|。GUKui一菇aa，LUAN Yunb Yu-jun、CHEN Shao—meng，WANG Hui-jin91,SUN Labof and Medical (Yangzhou dairybiologicaltechnologysafetycontrol；b，Yangzhou A— University．a，Key University cademy，Yangzhou225127，China) the mechanismof OnaCUtealcoholic inrats．Methods：Toestablishgn Abstract：TOsn-dyprotection s坼’舭M“thermophilus蓼I【02 liver细ury liver of seruln acutealcoholic modelandobservethe onthe ammotransferaseandinnaIll． injury improvementStreptococcusthennophilusgrx02 ofaCllte in callinducearemarkableincreasementoftheIcyels cytokme alcoholic rats．Alcohol ofrat’sserulTlALT．AST matoty aver嘶my and mako thelevelsoftumornecrosis MDA，Meanwhile,alcohol s够征∞母elevate and cartweaken of leukin一8(IL一8)ofⅫulnliver inrats．However，alcoholthe Alcohol homogenate a