乙酰半胱氨酸泡腾片联合布地奈德治疗特发性肺纤维化的临床疗效观察.docVIP

精品论文 参考文献 乙酰半胱氨酸泡腾片联合布地奈德治疗特发性肺纤维化的临床疗效观察 新疆医科大学第二附属医院呼吸科 乌鲁木齐 830063 【摘 要】目的：观察乙酰半胱氨酸泡腾片联合布地奈德治疗特发性肺纤维化的临床疗效。方法：选取我院呼吸科2012 年1 月－2015年6月住院治疗的IPF 患者30 例，随机分为两组，观察组给予布地奈德混悬液1mg/次，2次/d，每次15min，氧驱动雾化吸入。同时给予乙酰半胱氨酸泡腾片600 mg/次，3次/d，温开水溶解后服用。对照组给予泼尼松0.5 mg/（kgbull;d）分次口服，连用4 周后减量至0．25mg/（kgbull;d）。8周后对比两组临床疗效。结果：观察组呼吸困难程度、肺功能、血气水平改善程度均较治疗组有所提高，具有统计学意义（P ＜ 0.05），治疗过程中，观察组不良反应明显少于对照组。结论：乙酰半胱氨酸泡腾片联合布地奈德治疗能显著改善患者临床症状及肺功能，减少并发症的发生，提高患者生存质量，值得临床推广。 【关键词】乙酰半胱氨酸泡腾片；布地奈德；特发性肺纤维化 Clinical Efficacy of Acetylcysteine Effervescent Tablets Combine With Budesonide in the Treatment of Idiopathic Pulmonary Fibrosis Mu qingshuang，Han limei，Gu lixian，Department of Respiration，The Second Affiliated Hospital of Xinjiang Medical University.Urumq，830063，China. 【Abstract】 Objective to observe the clinical efficacy of acetylcysteine effervescent tablets combine with budesonide in the treatment of pulmonary fibrosis budesonide.Methods 30 cases of patients with idiopathic pulmonary fibrosis in our hospital from January 2012 to June 2015 were randomly divided into two groups：observation group and control group.Observation group was given budesonide suspension liquid 1 mg/time，2 times/d，each 15 min，oxygen atomization inhalation.While giving acetylcysteine effervescent tablets，600 mg/time，3 times/d，warm boiled water dissolves.Control group was given prednisone 0.5/（kg.d），by several times of oral，4 weeks after reduction to 0.25 mg/（kg.d）.After 8 weeks compared two groups of clinical curative effect.Results After treatment，the dyspnea score，pulmonary function，blood gas levels of observation group were significantly improved than the control group.The difference was statistically significant（Plt;0.05）.In the process of treatment，the adverse reactions of observation group were obviously less than the control group.Conclusion acetylcysteine effervescent tablets combine with budesonide therapy could significantly improve patients clinical symptoms，lung function and the quality of survival，and reduce com