乳腺导管内癌伴微浸润的病理和免疫组织化学特征分析.docVIP

精品论文 参考文献 乳腺导管内癌伴微浸润的病理和免疫组织化学特征分析 （内蒙古自治区人民医院病理科 内蒙古呼和浩特 010017） 【摘要】目的：分析乳腺导管内癌（DCIS-MI）伴微浸润的病理和免疫组织化学特征。方法：选取2014年5月-2016年5月期间我院收治已确诊的乳腺导管内癌患者80例为研究对象,根据不同病理特征分为实验组和对照组各40例，乳腺导管内癌伴微浸润患者（DCIS-MI）为实验组，导管内癌患者（DCIS）为对照组，分两组的病理和免疫组织特征。结果：实验组的腋窝淋巴以及乳头paget病情况与对照组无显著性差异，(Pgt;0.05)；但实验组的肿块最大直径2.5cm的比率显著高于对照组，(Plt;0.05)；此外，实验组的HER2、ER、PR、Ki-67表达以及caveolin-1阴性表达等情况与对照组比较均有显著性差异。结论：DCIS-MI在HER2、ER、PR、Ki-67表达以及caveolin-1阴性表达、肿块最大直径2.5cm发生率较高。 【关键词】乳腺导管内癌；免疫组织；病理 【中图分类号】R730.2 【文献标识码】A 【文章编号】1007-8231（2016）22-0006-02 【Abstract】Objective To analysis the breast intraductal carcinoma (DCIS - MI) associated with the pathological and immunohistochemical features of micro infiltration. Methods In May 2014 to May 2016 our hospital has confirmed 80 cases of patients with breast intraductal carcinoma as the research object, according to the different pathological features were divided into experimental group and control group, 40 cases of breast intraductal carcinoma with micro infiltration (DCIS - MI) as experimental group, patients with intraductal carcinoma (DCIS) as the control group, the pathological and immunohistochemical features of the two groups. Results s axillary lymphatic and nipple pagets disease of the experimental group with control group, there was no significant difference (P gt; 0.05); But the experimental group bump the ratio of maximum diameter of 2.5cm is significantly higher than the control group, (P lt; 0.05); In addition, the experimental group of HER2, ER, PR, Ki - 67 expression and caveolin - 1 negative expression had significant difference compared with controls, and so on and so forth. Conclusion DCIS - MI in HER2, ER, PR, Ki - 67 expression and caveolin - 1 negative expression, lumps were higher in maximum diameter of 2.5 cm. 【Key words】Breast intraductal carcinoma; Immune tissue; The pathological 近年来，随着医疗技术的进步，乳房检查的技术也随着提高，而乳腺导管内癌的检出率呈逐渐上升趋势[1]；免疫组化学双标记技术的应用在乳腺导管内