复方斑蝥胶囊辅助治疗老年淋巴瘤疗效观察.docVIP

精品论文 参考文献 复方斑蝥胶囊辅助治疗老年淋巴瘤疗效观察 杨玉兰（河南中医学院第一附属医院 河南郑州 450000） 【摘要】目的 观察复方斑蝥胶囊辅助治疗老年淋巴瘤疗效观察，分析复方斑蝥胶囊应用的临床价值。方法　将82例符合入组标准的淋巴瘤患者随机分为观察组41例和对照组41例，对照组进行CHOP方案化疗，21d为一个周期，治疗6个周期，观察组在对照组基础上，再口服复方斑蝥胶囊，每次3粒，bid，连服4个月。结果　①观察组总有效率为92.68%，对照组为68.29%，观察组的总有效率明显高于对照组，差异具有统计学意义，x2=8.083，Plt;0.05；②观察组出现白细胞减少、肝功能异常、消化道反应、心脏毒性的病例和发生率分别为19/46.34%、2/4.88%、15/36.59%、1/2.44%，其中白细胞减少、肝功能异常、消化道反应的发生率明显低于对照组，差异均具有统计学意义，Plt;0.05或Plt;0.01。结论　复方蝥胶囊辅助治疗老年淋巴瘤值得临床推广。 【关键词】复方斑蝥胶囊 老年淋巴瘤 【中图分类号】R273 【文献标识码】B 【文章编号】2095-1752（2012）20-0320-02 【Abstract】 Objective: To observe the effect of compound cantharidin capsule in the adjuvant treatment of elderly lymphoma, and to analysis the Clinical value of compound cantharidin capsule.Methods: 82 non lymphoma patients met inclusion criteria were randomly divided into 41 cases of observation group and 41 cases of control group. the control group were given CHOP chemotherapy , 21d for a period, treated for six cycles, the observation group were given oral compound cantharidin capsules on the basis of the control group, three each twice daily, and treated for four month. Results: ① The total effective rate of the observation group was 92.68%, the control group was 68.29%, the observation group efficiency was significantly higher, the difference was statistically significant, X2 = 8.083, P lt;0.05;② The cases and incidence of leukopenia, abnormal liver function, gastrointestinal reactions, cardiac toxicity were 19/46.34%, 2/4.88, 15/36.59%, 1/2.44%,The leukopenia, abnormal liver function, gastrointestinal reactions of the observation group were significantly lower than the control group, the differences were statistically significant, P lt;0.05 or P lt;0.01. Conclusion: Fufang Banmao capsule the adjuvant therapy for elderly lymphoma worthy of clinical application. 【Keywords】 Compound BanMao capsule The elderly lymphoma 恶性淋巴瘤是临床常见的起源于淋巴造血组织的恶性实体瘤之一，95%以上为非霍奇金淋巴瘤（NHL），弥漫性大B细胞淋巴瘤（DLBCL）是最常见的亚型,约