多西紫杉醇联合卡培他滨治疗进展期胃癌临床观察.docVIP

精品论文 参考文献 多西紫杉醇联合卡培他滨治疗进展期胃癌临床观察 马科 　　（商丘市第四人民医院内五科 河南商丘 476000） 　　【摘要】目的：研究多西紫杉醇联合卡培他滨治疗进展期胃癌的疗效。方法：选取我院2012年3月至2015年3月收治的60例胃癌患者，均经病理检查证实为进展期胃癌，随机分为观察组和对照组各30例，对照组患者给予多西紫杉醇、顺铂及5-氟嘧啶联合治疗。观察组患者给予多西紫杉醇联合卡培他滨药物治疗，比较两种治疗方法治疗进展期胃癌的总有效率和不良反应[2-3]。 结果：研究结果表明，两组患者的治疗有效率相比，差异无统计学意义（P＞0.05）。两组患者在Ⅲ-Ⅳ级手足综合征和骨髓抑制等不良反应率方面相比，差异有统计学意义（P＜0.05）。结论：紫杉醇联合卡培他滨治疗进展期胃癌效果明显，且安全性较高，值得临床推广。 　　【关键词】多西紫杉醇；卡培他滨；进展期胃癌 　　【中图分类号】R730.5 【文献标识码】A 【文章编号】1007-8231（2016）02-0032-02 　　 Docetaxel combined with capecitabine in patients with advanced gastric cancer clinical observation 　　 Ma Ke. Five Department of Shangqiu Fourth Peoples Hospital, Shangqiu, Henan 476000,China 　　【Abstract】Objective To study the curative effect of docetaxel combined with capecitabine in the treatment of advanced gastric cancer. Methods selected in our hospital March 2012 to 2015 March treated 60 cases of gastric cancer patients, confirmed by pathological examination for advanced gastric cancer, were randomly divided into observation group and control group with 30 cases in each, the control group were treated with docetaxel, cisplatin and 5-fluorouracil combined treatment. Patients in the observation group were treated with docetaxel combined with capecitabine therapy, comparison of two treatment methods in the treatment of advanced gastric cancer total efficiency and adverse reaction of [2-3]. Results The results of the study showed that there was no significant difference between the two groups (P gt; 0.05). There was significant difference between the two groups in terms of grade III - IV, hand foot syndrome and bone marrow depression (P lt; 0.05). Conclusion The effect of paclitaxel combined with gemcitabine in the treatment of advanced gastric cancer is obvious, and the safety is high, it is worth to clinical promotion. 　　【Key words】Docetaxel; Capecitabine; Advanced gastric cancer 　　胃癌是我国常见的恶性肿瘤之一，其病死率占恶性肿瘤的首位，并其发病率呈现上升趋势[1]。而进展期胃癌占整个胃癌的55%～75%；确诊的患者大约60%失去手术机会或者术后发生复发及转移[2]。因而