我院35例低分子右旋糖酐氨基酸注射液致ADR分析.docVIP

我院35例低分子右旋糖酐氨基酸注射液致ADR分析 饶芸 骆群 徐萍 王智 第三军医大学第一附属医院普通外科/微创胃肠外科中心 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的:了解低分子右旋糖酐氨基酸注射液致不良反应 (ADR) 发生的特点和规律, 为临床安全用药提供参考。方法:收集我院2010年1月-2017年1月上报的35例低分子右旋糖酐氨基酸注射液致ADR报告, 对患者性别、年龄、ADR报告类型和发生时间、原患疾病及既往药物过敏史、ADR累及器官/系统及临床表现、转归等进行回顾性统计分析。结果:35例低分子右旋糖酐氨基酸注射液致ADR报告中, 男性18例 (51.43%) , 女性17例 (48.57%) ;患者年龄最小11岁, 最大80岁, 平均年龄48.2岁。严重的ADR 4例 (11.43%) , 一般的ADR 31例 (88.57%) ;ADR在用药后10 min1 h发生率高 (71.43%) ;ADR所涉及的原患疾病以骨折 (14例, 40.00%) 和膝关节炎 (8例, 22.86%) 为主;ADR主要累及消化系统 (34.29%) 、循环系统 (22.86%) 和皮肤及其附件 (20.00%) 等;所有患者在停药及对症处理后均好转或治愈。结论:低分子右旋糖酐氨基酸注射液致ADR的发生率不高, 但可致严重的ADR, 护理人员可对其加强监护, 以减少并发症的发生, 避免医患矛盾。 关键词： 低分子右旋糖酐氨基酸; 不良反应; 合理用药; 护理; 作者简介：饶芸 副主任护师。研究方向:护理管理、患者安全管理。电话:023E-mail:maggie_ry@ 收稿日期：2017-05-24 Analysis of 35 Cases of ADR Induced by Low-molecular Dextran and Amino Acid Injection in Our Hospital RAO Yun LUO Qun XU Ping WANG Zhi Dept.of General Surgery/Center of Minimal Invasive Gastrointestinal Surgery, the First Affiliated Hospital of Third Military Medical University; Abstract： OBJECTIVE:To investigate the characteristics and the regularity of ADR induced by Low-molecular dextran and amino acid injection, and to provide reference for safe use of drugs in clinic. METHODS:Among 35 cases of ADR induced by Low-molecular dextran and amino acid injection were collected from our hospital during Jan. 2010-Jan. 2017. Those ADR cases were analyzed statistically in respects of patients gender and age, type and occurrence time of ADR cases, primary disease, allergic history, organs/systems involved in ADR, clinical manifestations, outcomes, etc. RESULTS:Among 35 cases of ADR induced by Low-molecular dextran and amino acid injection, there were 18 male (51.43%) and 17 female (48.57%) . The youngest patient was 11 years old, the oldest patient was 80 years old, the average age was 48.2 years. There were 4 cases of severe ADR (11.43%) and 31 cases of common ADR (88.57%) . ADR mostly occurred