B-blocker在慢性心力衰竭中的应用.pptVIP

无忧PPT整理发布 无忧PPT整理发布 Application of beta blockers in the treatmnet of patients with heart failure Clinical seven-year 06 Fujian Pronvncial Hospital  Chronic heart failure can improve the activity of sympathetic nervous system in patients with the extension of disease duration,it can lead to deterioration of cardiovascular system function .Beta blockers can inhibit the activity of the neuroendocrine,thus prevent the disease progression .Beta blockers is widely used in chronic heart failure. Preface Directory First， beta blockers Second, treatment mechanisms Third, evidence-based Fourth, guidelines recommend Fifth， rational use Distributed ◆ Human cardiac cells has three beta-blockers β1、β2、α1 ◆ β1 andβ2 receptors in normal human ventricular ratio: 70-80/20-30% ◆ Heart failure, due to selective β1 receptor down, β2 receptor accounts for 35-40% 1、Non-selective beta-two blockers Propranolol(普奈洛尔/心得安) and Plugmelol(塞吗洛尔) Mechanism ：Inhibition of cardiac, peripheral resistance increases, so that cardiac output decreased 2、selective beta-one blockers Metoprolol （美托洛尔/倍他乐克）、Bisoprolol(比索洛尔/博苏、康忻） 3、Both α1, β 1,β 2 blockers Labetalol(拉贝洛尔)、Carvedilol(卡维地洛/达利全、络德），Also known as a vasodilator effect of b 2 blockers Classification Mechanism for treatment of heart failure Reverse Myocardial remodeling Diastolic function Anti- ischemic Other Antiarrhy -thmic Systolic function Up β1 receptor signaling Mechanism --Total number of patients more than 20,000 cases, more than 20 placebo-controlled clinical study has confirmed: Reduce the risk of death Reduce heart failure symptoms To improve the patients clinical status Improve the general condition of the patient Reduce the combined end point of death and hospitalization evidence-based Three kinds of ? blockers can significantly reduce the mortality rate of