不同时间新辅助内分泌疗法对局部晚期前列腺癌疗效的影响.pdfVIP

不同时间新辅助内分泌疗法对局部晚期 前列腺癌疗效的影响 侯瑞鹏 李健 王凤玮 张志华 尉皓 唐涛 张华 [摘要] 目的 探讨局部晚期前列腺癌联合治疗中新辅助内分泌疗法( NHT)的理想方案。 方法 诊断明确的局部晚期（T3-4N0M0）前列腺癌患者60例，均采用NHT治疗方案。治疗前随机分为 3组，每组20例，各组行不同时间NHT，A组：2周NHT，B组：3个月NHT，C组：6个月NHT。结果 A、 B、C组患者NHT后前列腺特异抗原(PSA)中位值分别为24.88( 6.62～55.86)、0.20（0.05～12.07）和 0.07( 0.01～2.01) ng/ml，与治疗前比较差异均有统计学意义（均P= 0.00），组间比较差异有统计学意 义（均P= 0.00）。A、B、C组行NHT后前列腺体积分别为(49.50±14.19)、(47.35±17.99)和(36.15± 7.17)ml，B、C两组治疗前后前列腺体积比较差异有统计学意义(P=0.04、0.00)，治疗后A组与C组、 B组与C组比较差异有统计学意义(P=0.00、0.01)。A、B和C组治疗后最大尿流率（Qmax）平均值分别 为( 8.75±2.15)、(11.70±2.81)和（14.45±2.61）ml/s，B组和C组治疗前后比较差异有统计学意义 （均P= 0.00）,治疗后各组间比较差异有统计学意义（均P=0.00）。结论 NHT治疗时间至少应达到 3个月，能够达到降低PSA、缩小前列腺体积和提高Qmax的效果。 前列腺肿瘤；前列腺特异抗原；局部晚期；新辅助内分泌疗法 Effect of different time neoadjuvant hormornal therapy for locally advanced prostate cancer HOU Rui-peng LI Jian WANG Feng-wei ZHANG Zhi-hua WEI Hao TANG Tao ZHANG Hua Department of Urology, the Peoples Hospital of Tianjin, Tianjin 300121, China [Abstract] Objective To investigate ideal solution of neoadjuvant hormomal therapy (NHT) for locally advanced prostate cancer. Methods 60 patients diagnosed with locally advanced (T3-4N0M0) prostate cancer were treated with NHT. They were randomly divided into 3 groups of 20 cases. A group: NHT 2 weeks, B group: NHT 3 months, C group: NHT 6 months. Results The median PSA of A, B and C group after NHT were 24.88 (6.62-55.86), 0.20 (0.05-12.07) and 0.07 (0.01-2.01) ng/ml, respectively. There was statistically significance compared with those in untreatment ( all P =0.00). There was statistically significant (P = 0.00) among groups. The prostate volume of A, B and C group were (49.50+14.19), (47.35±17.99) and (36.15±7.17) ml, respectively. There was statistically significance in the B and C group compared with that in untreatment (P = 0.04, 0.00). There was statistically significant between A and C group and between B and C group (P =0.00, 0.01). The Qmax of A, B and C group were (8.75±2.15), (11.7±2.81) a