脑膜炎奈瑟氏菌逃避人类固有免疫系统的机制.pdfVIP

·188· ·综述· 脑膜炎奈瑟氏菌逃避人类固有免疫系统的机制 陈柳孙强明 【摘要】 脑膜炎奈瑟氏菌●Nm)引起的脑脊髓膜炎在世界范围内是一种具有严重危害性的传染性 疾病。因此研究其侵袭机制显得非常必要。Nm表现出对人类免疫系统的高度适应，通过其菌体自身结 构如荚膜、脂多糖及对宿主的分子模拟能有效地避开抗菌肽、补体系统、吞噬细胞等宿主固有免疫系统。 目前对脑膜炎奈瑟氏菌逃避及抵抗人类固有免疫系统的机制研究已取得了许多进展。 【关键词】脑膜炎奈瑟氏菌；固有免疫系统；逃避；机制 Meehanimas ofavoidanceofhostinnate Neisseria CHEN immunityby meningitidis Liu，SUNQiang— InstituteMedical MedicalSciencesand UnionMedical ming． of Biology，ChineseAcademyof Peking College， 650118．China Kunming author：SUN CorrespondingQiang-ming，E·mail：qmsunl972@yahoo．corn．ca isknown黯thecauseofbacterial 【Abstraa】Ne／sser／ameningitidis leading meningitisworldwide。and the host mechanisms evades iscmcial．Theinnateimmune understanding bywhichⅣ．meningitidisimmunity isvitalfor individuals has system evolved protecting againstpathogens．However．Ⅳ．meningitidismultiple mechanismstoavoid humanantimicmbial SOon． killingby cells，and peptides，complementsystem，phagocytic Bacterialstructuressuchas andthosewhich or an polysaccharidecapsule mimicbindhostmoleculesim· play role colonizationandinvasion．Here．weall onthe on recent portantinⅣ．meningitidies provideupdate findings thediversemechanismswhich avoidshumaninnateimmune by N．meningitidis system． immune 【Keywords】Neisseriameningitidis；Innatesystem；Avoid；Mechanism 脑膜炎奈瑟氏菌(Neisseria