慢性肝病与血清Pre S1-Ag、HBV DNA和HBVM相关性分析.docVIP

精品论文 参考文献 慢性肝病与血清Pre S1-Ag、HBV DNA和HBVM相关性分析 姚红玉 沈蓉 陈陶阳 樊健　　 　　[摘 要]目的 探讨血清Pre S1-Ag、HBV DNA以及HBVM在慢性肝病中的临床价值。方法 对338例慢性乙型肝炎、80例肝硬化和61例肝癌患者，检测其Pre S1-Ag、HBV DNA和HBVM的阳性状态及其差异，采用KaPPa一致性检验HBV Pre S1-Ag与HBV DNA的阳性一致性。结果 肝癌患者与Pre S1-Ag（39.34%）和HBV DNA（34.43%）的阳性水平显著低于肝硬化（48.75%，46.25%），更低于慢性乙型肝炎患者（63.02%，74.26%）。三组慢性肝病患者均以三种HBV模式为主，其中，HBsAg、抗HBe、抗HBc阳性模式较多发生肝硬化和肝癌。Pre S1-Ag与HBV DNA的阳性水平有良好的一致性。结论 慢性肝病与Pre S1-Ag、HBV DNA和HBVM具有相关性，HBVM不同模式存在状态与疾病转归有明显关系，Pre S1-Ag对判断HBV在感染与复制中具有重要临床意义。 　　[关键词]慢性肝病 Pre S1-Ag HBV DNA HBVM 相关性 　　An Analysis of the Correlation between Chronic Liver Disease and Serum Pre S1-Ag, HBV DNA and HBVM　　 　　Yao Hongyu, Shen Rong, Chen Taoyang, Fan Jian 　　Abstract: Objective To investigate the clinical value of serum Pre S1-Ag, HBV DNA and HBVM in chronic liver diseases. Methods Positive status of Pre S1-Ag, HBV DNA and HBVM of 338 cases of chronic hepatitis B, 80 patients with liver cirrhosis and 61 patients with liver cancer were tested to know their differences. The positive consistency of HBV Pre S1-Ag and HBV DNA were tested by KaPPa consistency test . Results The positive level of hepatocellular carcinoma patientsrsquo; Pre S1-Ag (39.34%) and HBV DNA (34.43%) was lower than patient with cirrhosis (48.75%, 46.25%), and even lower than patients with chronic hepatitis B (63.02%, 74.26%). Three groups of patients with chronic liver disease all mainly contains the three kinds of HBV mode, of which the HBsAg, anti HBe, anti HBc positive pattern were often found in liver cirrhosis and hepatocellular carcinoma. The positive level of Pre S1-Ag and HBV DNA have good consistency. Conclusion Chronic liver diseases is associated with Pre S1-Ag, HBV DNA and HBVM. Different mode of HBVM and its existing state have obvious relationship with the prognosis of the disease. Pre S1-Ag diagnosis has important clinical significance in the infection and replication of HVB.　　 　　Key words: chronic liver disease; Pre S1-Ag; HBV DNA; HBVM; correlati