探讨腺苷蛋氨酸联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症的临床效果.docVIP

精品论文 参考文献 探讨腺苷蛋氨酸联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症的临床效果 北安市二井镇医院自民分院 164003 摘要：目的 研究分析腺苷蛋氨酸联合熊去氧胆酸的临床疗效观察。方法 此次研究的对象是选取我院2012年11月～2014年10月收治的40例妊娠期肝内胆汁淤积症患者，将其临床资料进行回顾性分析，并在征得患者同意的情况下，采用随机分组的方式将患者平均分为观察组和对照组，对照组患者行熊去氧胆酸治疗，观察组患者行腺苷蛋氨酸联合熊去氧胆酸进行治疗，然后就两组患者的治疗效果进行综合性的比较和分析。结果 经过系统的治疗，两组患者在谷丙转氨酶、谷草转氨酶、直接胆红素、总胆红素及总胆汁酸指标上比较观察组下降程度高于对照组（Plt;0.05），皮肤瘙痒评分、剖宫产率及产后出血发生率和早产率比较，观察组均优于对照组（Plt;0.05）。结论 在妊娠期肝内胆汁淤积症的临床治疗中，腺苷蛋氨酸联合熊去氧胆酸进行治疗，临床效果显著。 关键词：妊娠期肝内胆汁淤积症；腺苷蛋氨酸；熊去氧胆酸 Abstract：Objective To observe the clinical curative effect analysis of adenosine methionine combined with ursodeoxycholic acid. Methods the research object is selected in our hospital in November 2012 to 2014 October were 40 cases of pregnancy intrahepatic cholestasis patients，their clinical data were retrospective analysis，and patient consent of the randomized patients were divided into the observation group and the control group，the control group was treated with ursodeoxycholic acid treatment，observation group were treated with ademetionine combined bear deoxycholic acid treatment，and the therapeutic effect of two groups of patients for a comprehensive comparison and analysis. Results after treatment，two groups of patients in the glutamic pyruvic transaminase（GPT），glutamic oxalacetic transaminase（got），direct bilirubin，total bilirubin and total bile acid index comparative observation group were lower than that of the control group（P lt; 0.05），and the incidence of preterm birth rate skin pruritus score，section Palace yield and postpartum hemorrhage observed group were superior to the control group（P lt; 0.05）. Conclusion in clinical treatment of gestational intrahepatic cholestasis，S-adenosyl methionine combined with ursodeoxycholic acid treatment，the clinical effect was remarkable. Keywords：intrahepatic cholestasis of pregnancy；S-adenosylmethionine；ursodeoxycholic acid 妊娠期肝内胆汁淤积症是临床上发生率相对比较高的一种妊娠期特有的并发症，生化上以肝内胆汁预计的血液指标异常为特征，该疾病患者出现产后出血、死产、死胎、胎儿窘迫及早产[1]的可能性比较大；从治疗的角度来看，完全治愈具有一定的难度，主要是以利肝和护肝为主；本研究采用对比的方式探讨腺苷蛋氨酸联合熊去氧胆