氟比洛芬酯注射液与术后镇痛研究.docVIP

精品论文 参考文献 氟比洛芬酯注射液与术后镇痛研究 四川省宜宾市第二人民医院麻醉科 644000 【摘 要】目的：观察氟比洛芬酯注射液在手术前超前镇痛应用对腹部手术后镇痛的影响与安全评价。方法：选择ASAⅠ-Ⅱ级腹部外科手术患者80例，随机双盲分为实验组和对照组，每组40例。实验组术前、术毕时分别应用氟比洛芬酯注射液1ml/kg缓慢静脉注射，术毕镇痛泵内应用芬太尼0.5mg加生理盐水至100ml。对照组术毕镇痛泵内应用芬太尼1mg加生理盐水至100ml。分别记录术后4、8、12、24h的视觉模拟评分（VAS）和不良反应及芬太尼的用量。结果：术后4、8、12h实验组的VAS评分明显低于对照组（Plt;0.05），术后24h无显著性差异，芬太尼用量实验组明显少于对照组（Plt;0.05），PCIA按压次数及不良反应无显著性差异。结论：氟比洛芬酯注射液超前镇痛对腹部手术后镇痛效果确切，减少了芬太尼的用量，不良反应发生率少。 【关键词】氟比洛芬酯注射液；腹部手术；术后镇痛 Flurbiprofen injection and postoperative analgesia He Changyou Liu Lian Bo Second Peoples Hospital of Yibin City，Sichuan Province，Department of Anesthesiology（644000） Abstract：Objective：Observation of flurbiprofen injection application of preemptive analgesia before surgery analgesia after abdominal surgery on the impact and safety assessment．Methods：Select ASA Ⅰ-Ⅱ grade abdominal surgery in 80 patients whose randomly divided into experimental group and control group 40 cases．Experimental group before and after operation application flurbiprofen，respectively 1ml/kg slow intravenous injection，after surgery 0.5mg fentanyl analgesia pump plus saline to 100ml．Control group after surgery 1mg fentanyl analgesia pump plus saline to 100ml．4，8，12，24 h after surgery were recorded VAS and adverse reactions，and fentanyl amount．Results：4，8，12 h after surgery the experimental group VAS scores were significantly lower than the control group (Plt;0.05)，after 24h there was no significant difference in fentanyl consumption was significantly less than the experimental control group (Plt;0.05)，PCIA pressing frequency and side effects no significant difference．Conclusion：Flurbiprofen injection preemptive analgesia on the exact analgesia after abdominal surgery，reducing the amount of fentanyl，a small incidence of adverse reactions． Keywords：Flurbiprofen injection；Abdominal surgery；Postoperative analgesia 【中图分类号】R323.3【文献标识码】A【文章编号】2096-0867（2016）-07-001-02 氟比洛芬酯注射液是一种以脂微球为载体的具有靶向镇痛作用的非甾类抗炎镇痛药，其到达炎症部位后通过抑制前列腺素合成，并降低脊髓、中枢的敏感性，从而减少痛觉冲动，发挥镇痛效应[1]