三磷酸胞苷在Duolite+A30+树脂上的交换过程研讨.pdfVIP

L033 三磷酸胞苷在Duolite A-30 树脂上的交换过程研究 阮文辉 肖明芳 吕浩 赵谷林 应汉杰** (南京工业大学制药与生命科学学院，南京210009) 要 根据CTP 在离子交换树脂上的吸附容量和分离因数的大小，确定Duolite A-30 树脂适合 CTP 与CDP，CMP 之间的分离。对CTP 在Duolite A-30 树脂上的吸附动力学和热力学研究表明， 在283.15K～303.15K 之间，CTP 的质量浓度在7.5g/L 以上时，Duolite A-30 树脂对CTP 的吸附 -7 2 -1 主要受颗粒扩散的控制，其有效扩散系数为D=3.47×10 cm ·s ，溶液的质量浓度≤1.0g/L 时， -4 -1 CTP 与Duolite A-30树脂之间的交换速率主要受液膜控制,其液膜扩散系数为K =4.112×10 ·s 。 f 同时测定了不同条件下三磷酸胞苷溶液在Duolite A-30 树脂固定床离子交换柱中的穿透曲线， 研究了进口浓度、进口流速、原料液温度、原料液的 pH 值及柱高对穿透曲线的影响。用二阶动 力学推动力模型描述固定床动态过程，考察了轴向返混对穿透曲线的影响，并从穿透曲线回归得 到总传质系数，模型计算值与实验数据符合良好。 关键词 三磷酸胞苷 离子交换 动力学 传质模型 THE ADSORPTION KINETIC AND THERMODYNAMIC STUDY OF CTP ON GELATION DUOLITE Ruan Wenhui, Xiao Mingfang, Lv Hao, Zhao Gulin and Ying Hanjie College of Life science and Pharmaceutical Engineering Nanji ng University of Technology, Nanji ng 210009, China ） Abstract Duolite A-30 resin is adapted to separate CTP from the mixture of CTP, CDP and CMP basing on the adsorption capacity and selectivity on the different resins. Equilibrium data for the adsorption of CTP from aqueous solutions with Duolite A-30 resin had been researched, which is correlated with a langmuir-type of isotherm equation. The kinetics and thermodynamics of ion exchange between CTP and OH ions with Duolite A-30 resin were studied. Meanwhile, the corresponding determining-rate-steps are ascertained and diffusion coefficients were calculated. The results showed that the ion exchange rate between CTP and Duolite A-30 resin is controlled by