炎琥宁注射液联合干扰素治疗小儿手足口病的临床观察.docVIP

精品论文 参考文献 炎琥宁注射液联合干扰素治疗小儿手足口病的临床观察 （甘肃省古浪县人民医院儿科 733100） 【摘要】目的：观察炎琥宁注射液联合干扰素治疗小儿手足口病的临床疗效。方法：手足口病患儿126例，治疗组63例，对照组63例，治疗组63例给予炎琥宁注射液联合干扰素alpha;1b治疗，对照组给予干扰素alpha;1b治疗；疗程5天，并根据病情给予相应对症支持治疗。对两组临床症状体征进行观察比较。结果：炎琥宁注射液联合干扰素治疗小儿手足口病时其退热时间、显效情况均优于单纯应用干扰素治疗组。结论：炎琥宁注射液联合干扰素治疗小儿手足口病总有效率优于单纯性应用干扰素治疗组，且不良反应不明显。 【关键词】 手足口病；炎琥宁；干扰素alpha;1b；小儿 【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752（2015）35-0117-02 【Abstract】Objective To observe the clinical efficacy of Yanhuning Zhusheye combined with interferon in the treatment of children with hand foot and mouth disease. Method of hand, foot and mouth disease in children in 126 cases, 63 cases in the treatment group, 63 cases in the control group, treatment group (63 cases) was treated with Yanhuning injection combined with interferon in the treatment, control group was treated with interferon in the treatment; the course of treatment was 5 days and according to the condition of give the corresponding symptomatic supportive treatment. The clinical symptoms and signs of the two groups were observed and compared. Results Yanhuning injection combined with interferon in treatment of children with hand, foot and mouth disease in the cooling time and effect were better than the simple application of interferon treatment group. Conclusion Yanhuning injection combined with interferon in the treatment of children with hand, foot and mouth disease total efficiency is better than the simple application of interferon in the treatment group, and adverse reaction is not obvious.. 【Key words】Hand foot and mouth disease Yan Huning interferon alpha 1b children 手足口病是手足口病(HFMD)是一种儿童传染病，主要是由肠道病毒柯萨奇病毒A16型(CoxA16)和肠道病毒71型(EV 71)最为常见引起，5岁以下易得。夏秋之交都有发病，9月是高峰期，典型的起病过程是中等热度发热(体温在39℃以下)，进而出现咽痛，幼儿表现为流口水、拒食，可引起手、足、口腔等部位的疱疹，嗓子里还有一些小水泡，没有并发症的患儿，一周左右即可痊愈。少数患儿有神经系统症状，并发无菌性脑膜炎和皮肤继发感染，极少有后遗症；少数患儿可引起心肌炎、肺水肿、无菌性脑膜脑炎等致命性并发症[1]。 1.资料与方法 1.1临床资料 我院2013年7月～2015年7月诊断为手足口病患儿126例，发病均在24小时内，随机分为琥宁注射液联合干扰素治疗组63例，男32例，女31例，年龄1