甘精胰岛素联合门冬胰岛素强化治疗2型糖尿病的疗效观察.docVIP

精品论文 参考文献 甘精胰岛素联合门冬胰岛素强化治疗2型糖尿病的疗效观察 钱华翔 陆超 （常州市第四人民医院 213000） 　　【中图分类号】R969 【文献标识码】A【文章编号】1672-5085（2013）30-0109-02 　　【摘要】 目的 探讨甘精胰岛素联合门冬胰岛素强化治疗2型糖尿病中的有效性。方法　36例2型糖尿病患者随机分为2组： A组20例，B组16例。A组给予甘精胰岛素和门冬胰岛素治疗，B组给予预混胰岛素治疗。观察空腹血糖、三餐后2h血糖、达标时间、胰岛素用量、每日血糖波动差值等指标。结果　（1）2组治疗后空腹血糖、餐后2h血糖均较治疗前明显降低（P值lt;0.01）。（2）治疗后2组空腹血糖、餐后2h血糖、胰岛素用量无显著性差异（P值gt;0.05）；达标时间A组明显短于B组（P值lt;0.05）；每日血糖波动A组明显小于B组（P值lt;0.05）。结论　甘精胰岛素联合门冬胰岛素强化治疗2型糖尿病疗效较好，尽早使血糖平稳达标，并且减少每日血糖波动。 　　【关键词】 2型糖尿病 甘精胰岛素 门冬胰岛素 强化治疗 　　Efficacy observation of the intensive therapy of insulin glargine combined with insulin aspart for patients with type 2 diabetes 　　Qian Hua-xiang, Lu Chao 　　(The Fourth Peoples Hospital of Changzhou, Jiangsu Changzhou 213000) 　　【Abstract】 Objective: To investigate the efficacy of the intensive therapy of insulin glargine combined with insulin aspart for patients with type 2 diabetes.Methods: 36 patients with type 2 diabetes were randomly divided into two groups: A group of 20 cases, B group of 16 cases. Group A received insulin glargine and insulin aspart, group B were given pre-mixed insulin therapy. Fasting blood glucose, 2h plasma glucose after meals, standard time, insulin dosage, the daily fluctuations in blood glucose difference and other indicators were observed. Results：(1) The values of fasting blood glucose, postprandial 2h plasma glucose after treatment were significantly lower in both groups (P lt;0.01). (2) After treatment, fasting blood glucose, postprandial 2h plasma glucose, insulin dosage were no significant difference in both groups (Pgt; 0.05); standard time in group A was significantly shorter in group B (P lt;0.05); daily blood glucose fluctuations in group A significantly less than in group B (P lt;0.05). Conclusion：Intensive therapy of insulin glargine combined with insulin aspart for patients with type 2 diabetes has better efficacy, as soon as possible so that blood glucose stable, and reduce daily blood glucose fluctuations. 　　【Key words】Type 2 diabetic mellitus