鸦胆子油乳注射液联合GP方案治疗中晚期非小细胞肺癌临床观察.docVIP

精品论文 参考文献 鸦胆子油乳注射液联合GP方案治疗中晚期非小细胞肺癌临床观察 青岛市胶州中心医院放疗科 266300 摘要：目的 观察鸦胆子油乳注射液联合GP（吉西他滨+奈达铂）方案治疗中晚期非小细胞肺癌（NSCLC）的疗效、毒副反应及生活质量改善情况。方法 将46例中晚期N S C L C患者随机分为治疗组（A组）23 例和对照组（B组）23例．A组给予鸦胆子油乳注射液联合GP化疗方案治疗，B组单用GP化疗方案治疗，对比分析两组患者临床疗效、化疗毒副反应以及生活质量情况。结果 两组间有效率比较差异无统计学意义（P＞0.05）；A组骨髓抑制及关节肌肉疼痛发生率低于B组（P＜0.05）；A组生活质量改善率明显优于B组（P＜0.05）；结论 鸦胆子油乳注射液联合G P化疗方案治疗中晚期非小细胞肺癌可明显改善患者生活质量，减轻化疗毒副反应，优于单纯化疗，值得临床推广应用。 关键词：鸦胆子油乳注射液；非小细胞肺癌；GP方案；化疗 [Abstract]Objective To observe the efficacy，toxicity and quality of life improvement of brucea javanica oil emulsion combined with GP（gemcitabine plus nedaplatin）regimen in treatment of advanced non small cell lung cancer（NSCLC）.Methods 46 patients with advanced NSCLC were randomly divided into control group（A group）23 patients and treatment group（B group）23 patients．A group patients were treated with brucea Javanica Oil+ GP treatment，and B group patients were treated with GP regimens.The clinical eficacy，toxicity and quality of life situation of the two groups were comparatively analyzed.Results The efficiency of the A group and B group were no statistical differences（P＞0.05）；the diferences of myelosuppression and pain incidence ra te between two groups were statistically significant（P＜0.05）；the quality of life in the A groupwa significantly better than that in the B group，with significant statistical diferences（P＜0.05）.Conclus ions Brucea javanica oil injection and GP chemotherapy in treatment of advanced NSCLC Can significantly improve patient quality of life，imp rove symptoms，and reduce the side efects of chemotherapy，which is worthy of clinical application. [Key words]Brucea javanica oil emulsion；Non-small cell lung cancer；GP；Chemotherapy 我国是全球肺癌高发区，肺癌病死率已位居我国恶性肿瘤病死率之首，且发病率正逐年攀升。非小细胞肺癌约占肺癌总数的80%，因发病早期多无症状，确诊时多为中晚期，预后差，放化疗是目前主要治疗模式，患者常需多程化疗，而化疗毒副反应严重影响患者的生活质量，临床治疗中如何减轻毒副反应，并进一步提高疗效成为关注焦点。 2012年8月至2013年10月期间，我科收治的46例行GP方案化疗的中晚期NSCLC患者随机分成两组．分别使用或不使用鸦胆子油乳注射液，在临床疗效、化疗毒副反应以及生活质量改善三个方面的差异进行对比观察分析，现报告如下： 1 材料与方法 1．1 临床资