鼻咽癌单纯放疗和联合放化疗并医院感染情况调查与分析.docVIP

精品论文 参考文献 鼻咽癌单纯放疗和联合放化疗并医院感染情况调查与分析 林坤花 陈丽民 卓延红 陈伟霖 　　（福建医科大学附属医院漳州市医院放疗科 363000） 　　【摘要】目的 调查分析鼻咽癌患者单纯放疗和联合放化疗医院感染情况。方法 对在2011-1-1至2013-7-31期间我院收治的鼻咽癌病例436例的临床资料进行回顾性调查分析医院感染情况。结果 在436例鼻咽癌患者中并发感染的病例有152例，感染率为34.86%；前者平均住院天数为54.8天、后者63天；不同治疗方法出现感染的比例明显不同：单纯放疗、诱导化疗、同期放化疗感染率为10.2%、36.7%和46.3%（P值均lt;0.05）。感染发生的主要部位依次为口腔和咽部粘膜125例,占82.2%；肺部16例，占10.5%；气管-支气管13例，占8.5%；其中多部位感染8例，占5.3%。感染的病原菌有68例真菌感染或合并真菌感染，达44.7%，95例分离出病原菌106株，前三位为鲍曼不动杆菌33株（33/95、构成比34.7%），肺炎克雷伯氏31株（31/95、构成比32.6%），大肠埃希菌20株（20/95、构成比21.1%）；男女性别感染发生比例无差别；不同年龄段除＜40岁感染率较低以外（21.5%，Pgt;0.05），40-75岁感染发生率亦无差异。结论 鼻咽癌放疗患者联合化疗特别是同步化疗医院感染明显增加，与住院时间长、治疗毒性反应增加有关。 　　【关键词】医院感染 鼻咽癌 放射治疗 同期放化疗 诱导化疗 　　【中图分类号】R730.5 【文献标识码】A 【文章编号】2095-1752（2013）36-0064-02 　　Nasopharyngeal carcinoma radiotherapy and combined radiation and chemotherapy the investigation and analysis of infection in hospital 　　Huang jianli,Lin kunhua,Chen limin，Chenweilin,Zhuo yanhong. Department of radiotherapy Oncology, Zhangzhou Municipal Hospital of Fujian. 　　【Abstract】Objective: Investigation and analysis of patients with nasopharyngeal carcinoma radiotherapy and radiotherapy combined with chemotherapy in hospital infection. Methods :from 2011-1-1 to 2013-7-31 during the NPC patients admitted in our hospital 436 cases of clinical data were retrospectively analyzed infection in hospital. Results: in 436 cases of nasopharyngeal carcinoma patients complicated with infection in 152 cases, the infection rate was 34.86%; the average hospital stay was 54.8 days, 63 days for the latter; different treatment infection ratio significantly different: radiotherapy, chemotherapy, radiotherapy and chemotherapy infection rate was 10.2%, 36.7% and 46.3% (all P lt;0.05). The infection mainly occurs in the oral and pharyngeal mucosa in 125 cases, accounting for 82.2%; lung in 16 cases, accounting for 10.5%; trachea - bronchus in 13 cases, accounting for 8.5%; the infection of multiple sites in 8 cases, acc