白介素-6在多发性骨髓瘤中的作用及靶向治疗研究进展.pdfVIP

18 卷 4 期 生命科学研究 灾燥造援员8 晕燥援4 圆园14 年8 月 蕴蚤枣藻 杂糟蚤藻灶糟藻 砸藻泽藻葬则糟澡 Aug. 圆园14 综 述 白介素-6 在多发性骨髓瘤中的作用及靶 向治疗研究进展 杨, 胡维新* (中南大学生命科学学院, 中国湖南长沙410078) 摘 要: 多发性骨髓瘤(multiple myeloma, MM)是浆细胞克隆性增殖和异常积聚的一种恶性疾病 白介素-6 (IL- 6) 是MM 最关键的生长因子, 能参与细胞内信号转导, 促进细胞生长增殖, 其基因异常表达或分泌往往引起 MM 的发生 IL-6 在MM 中的作用居多, 如参与信号转导尧免疫反应以及增殖尧生存尧耐药性等 目前依据IL-6 在MM 发生发展中的作用, 针对IL-6 在MM 的靶向治疗已成为MM 治疗的趋势 靶向治疗主要在信号通路尧 骨髓微环境尧免疫反应以及遗传表观学等方面展开研究, 并在临床应用上发挥关键性作用 关键词: 多发性骨髓瘤; 白介素-6; 靶向治疗 中图分类号: Q71 文献标识码: A 文章编号: 1007-7847渊2014 冤04-0363-04 Effect of IL-6 and Research Progresses for Targeting Treatment in Multiple Myeloma ZHOU Yang, HU Wei-xin* (School of L if e Sc iences, Central South Univ ers ity, Changsha 410078, H unan, China) Abstract: Multiple myeloma (MM) is a type of cancer occurring in the bone marrow due to malignant trans formation and clone expansion of plasma cells. Interleukin-6 (IL-6), which is one of the most important and well characterized cytokines in MM, triggers cellular signaling, promotes MM cell growth and survival, and confers drug resistance. The abnormal expressions of IL-6 gene or secretion often lead to MM. IL-6 has var ious effects in MM cells, such as signaling transmission immune response, proliferation, survival, drug resis tance, etc. At present, on the basis of IL-6 in its role in the development of MM, MM targeted therapy has become the trend of treatment in MM. Further studies on targeted therapy of IL-6 in MM are being done, mainly in the signal path, the bone marrow microenvironment, immune response and apparent