[医学]浙江大学医学免疫学经典课件免疫07-白细胞分化抗原.pptVIP

Downloaded from: StudentConsult (on 1 June 2006 03:50 PM) ? 2005 Elsevier 3，CD40 interacts with CD40L (Th cell) 4，CD80(B7.1), CD86(B7.2) expressed on activated B cells 5，ICAM-1, LFA-1 三、Ig Fc Receptor Cell adhesion molecules CAM: A group of proteins involved in adhesion of cell to cell or cell to extra-cellular matrix (ECM), such as ICAM-1, ICAM-2, ICAM-3, VCAM-1 and PECAM etc. Cell adhesion molecules Cellular recognition, activation, proliferation, differentiation, migration Immune response Inflammation Tumour The denomination of adhesion molecule and CD molecule is based on different aspects. Adhesion molecules are classified by adhesive function. Most adhesion molecules possess a CD number, however, some do not. Cell adhesion molecules Categories of CAM 1. Integrin family 2. Selectin family 3. Cadherin 4. IGSF (Ig superfamily) 5. Mucin-like family 6. Others:PNAd, CD44, CD36 1, Integrin Family 1)Integrin:Mediate adhesion of cell and extracellular matrix 2)Elementary structure: heterodimer of ?, ? chain 14 kinds of ? subunits, 8 kinds of ? subunits Integrin 3)Integrin family β1: VLA(very late appearing antigen) β2: LFA-1(lymphocyte function associated antigen-1) ligand:ICAM-1,2,3 β3: gpⅡbⅢa 4)Distribution:Expressed extensively 2、Selectin Family Selectins are carbohydrate-binding proteins present on leukocytes, endothelial cells, and platelets; their principal function is to regulate the migration of leukocytes to various tissues Selectin Size Distribution Ligand L-selectin (CD62L) 90-110 kD (variation due to glycosylation) Lymphocytes (high expression on naive T cells, low expression on activated effector and memory cells) Sulfated glycosamino-glycans on GlyCAM-1, CD34, MadCAM-1, others E-selectin (CD62E) 110 kD Endothelium activated by cytokines (TNF, IL-1) Sialylated Lewis X and related glycans (e.g., CLA-1) on various glycoproteins P-selectin (CD62P) 140 kD Storage granules and surface of