[医学]生物化学英文版习题.docVIP

Fuel Metabolism PART 1: Structure and Function of Protein Directions: Each of the numbered items or incomplete statements in this section is followed by answers or by completions of the statement. Select the one lettered answer or completion that is best in each case. Questions 9 and 10 Use the structure to answer questions 9 and 10： Asp-Ala-Ser-Glu-Val-Arg 9. The C-terminal amino acid of the hexapeptide shown is (A) alanine (B) asparagine (C) aspartate (D) arginine 10. At physiologic pH (7.4), this hexapeptide will contain a net charge of (A) -2 (B) -1 (C) 0 (D) +1 (E) +2 11. Which one of the following types of bonds is covalent? (A) Hydrophobic (B) Hydrogen (C) Disulfide (D) Electrostatic 13. Which one of the following conditions causes hemoglobin to release oxygen more readily? (A) Metabolic alkalosis (B) Increased production of 2,3-bisphosphoglycerate (BPG) (C) Hyperventilation, leading to decreased levels of CO 2 in the blood (D) Replacement of theβsubunits with γsubunits 14. Production of which of the following proreins would be most directly affected in scurvy? (A) Myoglobin (B) Collagen (C) Insulin (D) Hemoglobin 15. The active site of an enzyme (A) is formed only after addition of a specific substrate (B) is directly involved in binding of allosteric inhibitors (C) resides in a few adjacent amino acid residues in the primary sequence of the polypeptide chain (D) binds competitive inhibitors 16. An enzyme catalyzing the reaction E + S = ES →E + P was mixed with 4 mM substrate. The initial rate of product formation was 25% of Vm. The Km for the enzyme is (A) 2 mM (B) 4 mM (C) 9 mM (D) 12 mM (E) 25 mM 17. The velocity (v) of an enzyme-catalyzed reaction (A) decreases as the substrate concentration increases (B) is lowest when the enzyme is saturated with substrate (C) is related to the substrate concentration at lh Vm (D) is independent of the pH of the solution Questions 18 and 19 Refer to the following reactio