3.0t mridti技术多参数值评价原性开角型青光眼视路损害的分析 word格式.docxVIP

.单眼视功能损害的青光眼患者对侧正常眼与正常对照组 DTI 参数值比较，部分参数值有统计学差异（p＜0.05）。.青光眼临床严重程度分级与 DTI 部分参数有良好相关性（p＜0.05）。.与匹配的正常人对比,青光眼组视神经 FA 值、RA 值，Dav 值、VrA 值的 改变均大于视放射(p＜0.05)。.正常对照组两侧视神经、视放射 DTI 值均无统计学差异(p＞0.05)。结论 青光眼是累计视神经及视放射的复杂神经系统性疾病，是双眼发生的疾病， 视神经比视放射受到的损害严重。提示 DTI 多参数可用于原发性开角型青光眼的早期诊 断并可对疾病严重程度做出辅助判断。关键词原发性开角型青光眼, 磁共振扩散张量成像,视神经,视放射Study of the injuries of visual pathway with MRI- DTI multiparameter on patients with primary open angle glaucomaABSTRSCTObjectiveTo evaluate the changes of the visual pathway of POAG ,by MR-DTI, and determine whether DTI-derived parameters correlate with disease severity.Methods30 patients with known POAG and 35 age-matched healthy volunteers were examined.Disease severity was clinically assessed with use of a six-stage system based on static threshold visual field parameters.All subject underwent imaging on a GE signa HD-xt3.0T system utilizing a DTI sequence and normal MRI sequence .All the original data were processed by GE workstation. fractional anisotropy ( FA),average diffusion coefficient( Dav), relative anisotropy (RA ), volume ratio aniso(VrA),maps of dorsal visual pathway in the POAG patients were compared with the healthy controls and the correlation between the POAG group and the clinical stages were further made.p0.05 is statistically meaningful.Results 1.eight patients,fifty optic nerves of the POAG patients look like more tenuity，optic nerve sheaths turn a little widen ,but the signal Was normal.The fiber of optic nerves and radiation were sparseness compare with normal groups.In POAG group,the FA 、 VrA 、 RA values of optic nerves and radiationdecreaseobviously（p0.05）, the Dav values increase obviously（p0.05）.The DTI values of the normal side of POAG patients with monocular damage compare with normal groups is statistically meaningful.The disease severity of POAG patients was correlate with part DTI-derived parameters . 5.Compare with normal groups ,the optic nerve presented more severe injuries than that of the optic radiation (p 0.0