CRRT(讲稿CME)课件.pptVIP

20 21 22 42 Inborn Crush Tumor lysis 先天性积压肿瘤溶解 Introductions Children can not be considered to be adults There are significant differences between adult and pediatric patients Common types of drug-related problems in the pediatric population include drug dosages, available formulations,medication administration,compliance and pharmacokinetics and phamachological differences Renal failure patients often have significantly delayed growth. Growth hormone may be prescribed in an effort to increase their growth. Introductions :Frequency Frequency Adult : Pediatrics Incidence 8 : 1 Prevalence 10 : 1 Introductions : Demographic issues Age group 2000 2001 2002 0-4 3 6 8 5-9 2 4 5 10-14 1 2 4 15-19 2 2 3 20-44 34 36 45 45-64 23 27 33 64-74 65 128 234 PMP / year RF incidence in GDPPH by age at ESRD therapy GN (23%) PN / Obstr. uropathy (25%) Hereditary nephritis (16%) Hypo-/dysplasia (2%) Vascular dis. (5%) ARF Introductions :Causes Disease in Children SNUH, Korea Introductions : Causes of ESRD in Children Diagnosis No. % Aplastic/Hypoplastic/dysplastic kidneys 425 15.0 Focal segmental glomerulosclerosis 418 14.8 Obstructive Uropathy 317 13.1 Systemic immunological disease 210 7.4 Chronic glomerulonephritis 110 3.9 Reflux nephropathy 100 3.5 Hemolytic uremia syndrome 92 3.3 Polycystic kidney disease 89 3.1 Syndrome of agenesis of abd. musculature 66 2.3 Congenital nephrotic syndrome 65 2.3 Medullary cystic disease/juvenile nephronophthisis 61 2.2 Idiopathic crescentic glomerulonephritis 60 2.1 Pyelonephritis/interstitial nephritis 56 2.0 Familial nephritis 53 1.9 Renal infarct 48 1.7 Membranoproliferative glomerulonephritis type 1 46 1.6 cystinosis 44 1.6 Membranoproliferative glomerulonephritis type 2 29 1.0 Willm’s tumor 22 0.8 Drash syndrome 21 0.7 Oxalosis 18 0.6 Membranous nephropathy 13 0.5 Sickle cell nephropathy 11 0.4 Diabetic glomerulosclerosis 4 0.1 Other 285 8.3 Unknown 161 5.7 Total 2828