Paul_Burrows 如何做.pdfVIP

Paul E. Burrows PhD ScienceScience andand TechnologyTechnology ConsultantConsultant Reata Research, Kennewick, WA SSociietty ffor NNucllear MMedidiciine MMollecullar IImagiing SSummitit, Albuquerque, NM, Jan 31- Feb 1, 2010  Why Bother? ◦ Nanoscale materials have unique and useful ◦ Nanoscale materials have unique and useful properties not predictable from bulk characteristics. ◦ Few standards or gguidelines exist. ◦ NGO activity risks distorting public opinion and chilling development. ◦ Nanotechnology offers the opportunity to get it righht ffrom thhe bbeginning.  How to Define Nanotechnology.  Dealing With the Complex Life-Cycle. ◦ Life-cycle risk management frameworks.  Communication is Critical!  Unbounded Problem? ◦ “Nanoscale” represents an infinite class of materialsmaterials.  Poor Controls ◦ From personal experience, it can be a challenge to buy the same sample of a nanoscale material twice. ◦ Nanoparticles are not monodisperse.  What is important? ◦ Dose by mass? By surface area? ◦ IfIf a goldld nanopartiiclle iis taggedd wiithh an antibiboddy ((or radionuclide) how relevant is the toxicity of gold nanoparticles? ◦ What changes with time? (aggregation?)  How to prevent precautionary approaches leading to paralysis in the context of incomplete data sets? : 1 – 100nm Worse: Anything less than 100nm Even worse: Anyythingg with one dimension less than 100nm “If you can see“If you can see itititit withwithwithwith that,that,that,that, itititit’’ssss notnot nanonano!”!” What is different about the nanoscale