erk12通路抑制剂u0126与舌鳞癌细胞cal27生物学行为的相关性研究word格式论文.docx

独创性声明本人声明所呈交的学位论文是我个人在导师指导下进行的研究工作及取得的研究成果。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本声明的法律结果由本人承担。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。本论文属于保密□，在年解密后适用本授权书。不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录英文缩写词表······································································1中文摘要············································································2英文摘要············································································3正文前言············································································5材料和方法···································································6结果·········································································· 10讨论·········································································· 16参考文献···································································· 18综述················································································ 21参考文献·········································································· 35致谢················································································ 45英文缩略词表AbbreviationsRasRatsarcomaproto-oncogene小鼠肉瘤原癌基因ERKsExtracellularsignal-regulatedkinase细胞外信号调节激酶MAPKMitogen-activatedproteinkinase有丝分裂原活化蛋白激酶NGFNerveGrowthFactor神经生长因子PDGFPlateletDerivationGrowthFactor血小板衍生生长因子VEGFRVascularendothelialgrowthfactorreceptor血管内皮生长因子受体RTKsReceptortyrosinekinases受体酪氨酸激酶FTIsFarnesyltransferase inhibitors法尼基转移酶抑制剂FGFRFibroblastGrowthFactorReceptor成纤维细胞生长因子受体RECISTResponseEvaluationCriteriaInSolidTumors实体瘤疗效评价标准GTPGuanosinetriohosphte三磷酸鸟苷RafRatfibrosarcoma小鼠纤维肉瘤PI3KPhosphatidylinositol3-kinase磷脂酰肌醇3-激酶FITCFluoresceinisothiocanate异硫氰酸荧光素AKTApoptosissignal-regulated凋亡信号调节激酶GDPGuanosine diphosphate二磷酸鸟苷PKCProteinkinaseC蛋白激酶C中文摘要ERK1/2通路抑制剂U0126与舌鳞癌细胞CAL-27生物学行为的相关性研究华中科技大学同济医学院附属同济医院口腔医学中心研