急性淋巴细胞白血病低危组复发儿童临床相关性分析-clinical correlation analysis of relapsed children in acute lymphoblastic leukemia low-risk group.docx

下载文档 降价啦

3
0
约2.09万字
约 26页
2018-05-24 发布于上海
举报
版权申诉
保障服务

急性淋巴细胞白血病低危组复发儿童临床相关性分析-clinical correlation analysis of relapsed children in acute lymphoblastic leukemia low-risk group.docx

1、本文档共26页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

急性淋巴细胞白血病低危组复发儿童临床相关性分析-clinical correlation analysis of relapsed children in acute lymphoblastic leukemia low-risk group

AbstractObjective:Thispaperaimstoanalyzethechemotherapydataofchildhoodacutelymphoblasticleukemia(ALL)inlow-riskgroupintheAffiliatedHospitalofQingdaoUniversityandtoexploretherelevantfactorsofrecurrenceinthelow-riskchildrengroup.Methods:SelectingcaseswerediagnosedasB-typelow-riskgroupfromMay1,2005toApril30,2009inpediatrichematologyofourhospitalthroughretrospectivestudyandweretreatedwiththeschemeofShanghaiChildren’sMedicalCentre-AcutueLymphoblasticLeukemia-2005.IntheendofSeptember30,2011,thestudyhasexcludedtheabandonedandlostfollow-upcasesandmadeastatisticanalysiswiththerestofdata.Thestudycontains45casesdiagnosedasB-typelow-riskALL,amongofwhich,recurrencegroupwasconsistedof6cases,3malecasesand3femalecasesrespectively.Intherestof39cases,6caseswiththesamegenderandsimilarbodysurfaceareaswereselectedascontrolgrouptocollectandprocessclinicaldata.IndependentsampleT-testwascarriedouttoanalyzethedifferencesamongthemeanvalueoftestsamples.AllthedatainthestudyareprocessedbySPSS17.0.Results:1.Thecomparisonofclinicaldatabetweenrecurrencegroupandcontrolgroupbeforetreatment:therewerenosharpdifferences(Pvalue0.05)ingeneralconditionofattack,fusiongenandchromosome.2.TreatmentCondition:(1)Mperiod:Thetreatmentdurationofrecurrencegroupwasmuchlonger(p=0.047).(2)Infectionfrequency:recurrencegrouphasincreasedrapidly(p=0.049)inCs1,while,durationofanti-infectiontherapywasnosharpdifferencesinthefirstthreephases(Pvalue0.05).3.Thenumberoflumberpunctuateandbloodinfusion:therewerealsonoobviousdifferencesinthenumberoflumberpunctuate,infusionofredbloodcellsandplatelets(Pvalue0.05).4.Theutilizationofchemotherapydrugs:Inthefirstthreemonths,theintensityutilizationofcytarabine,6-mercaptopurineandmethotrexateofrecurrencegroupwasmuchlowerthantheintensityofthatofcontrolgroup(Pvalue0.05).Conclusion:1.AsfortreatmentdurationinMperiod,therecurrencegroupismuchlongerthancontrolgroup,whichindicatestheextensionoftreatmentdurationinMwouldcauserecurrence.2.Thetimeofinfectionfrequencyofrecurrencegroupismuchmorethanthat