家兔烧伤早期痂下水肿液中白蛋白吸收现象及药代动力学观察-study on albumin absorption and pharmacokinetics in the early eschar edema fluid of burn rabbits.docxVIP

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家兔烧伤早期痂下水肿液中白蛋白吸收现象及药代动力学观察-study on albumin absorption and pharmacokinetics in the early eschar edema fluid of burn rabbits.docx

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家兔烧伤早期痂下水肿液中白蛋白吸收现象及药代动力学观察-study on albumin absorption and pharmacokinetics in the early eschar edema fluid of burn rabbits

（两者相差 103 倍）。二、在家兔烫伤后分布相半衰期 t1/2α 明显缩短，曲线下面积 AUC 明显增大，说明在烧伤等损伤因素的作用下，组织局部伴有炎症反应，皮下组织的大分子物质的吸收更早，吸收速度与数量会成倍增加。三、随着伤情的加重，实验组吸收相半衰期 t1/2α 明显缩短，曲线下面积 AUC 明显增大。说明在一定的范围内，伤情越重，皮下组织对大分子的吸收更早，吸收的速度与数量会更大。关键词：烧伤；痂下水肿液；人白蛋白；药代动力学。Absorption of albumin in the subeschar tissue fluid and its pharmacokinetics of the burned rabbitsMaster Student: Wang Zhen Supervisor: Professor Rong Xin zhou Major: Department of BurnAbstractAlbumin can penetrate into the subeschar fluid (STF) and retent in it at the early stage after burn. These albumin would cause a decreasion of the plasma protein concentration, which resulting a sharp decline of the plasma colloid osmotic pressure (COP) and an increasion of the tissue fluid COP, and also enhancing the formation of edema after burn, that leading to further varieties of physiological and pathological changes of the body after burn.Vascular permeability would be increased after injury, the protein in the burn subeschar liquid are similar to serum levels, approximately 80% of plasma protein mainly albumin. Albumin infiltrated into and retented in subeschar fluid, that lowered the plasma protein concentration. But the albumin would keep in a stable state? Or it could be leaked out and absorpted as the small molecules? And the albumin returned could still play a relevant physiological function? All these need to be answered through the experiment.Our study tried to reveal the patterns of albumin distribution in the subeschar fluid. We establish the burned rabbit model, inject human albumin as tracer albumin into the subeschar of the burned rabbits, and then test the concentration of human albumin in blood to observe the dynamics parameters, analyze the pharmacokinetic changes, and finally we discovered some useful things on its distribution patterns.ObjectiveWe establish the burn model of rabbits and inject human albumin into their subscar. Test human albumin concentration of the blood to observe the dynamics of albumin, and then analyze the pha