骨质疏松相关管理进展 .ppt

Advances in osteoporosis ;-New findings regarding the pathophysiology of osteoporosis. -Identifying who needs to be treated. -Current treatment guidelines. -Monitoring therapy. -Areas of future development. ;Impact of osteoporosis;In 2002 NOF(National Osteoporosis Foundation) published the projected prevalence of those aged 50 and older based on yr 2000 census3: 2002 2010 2020 Women with osteoporosis: 7.8 9.1 10.5 Women with low bone mass: 21.8 26 30.4 Men with osteoporosis: 2.3 2.8 3.3 Men with low bone mass: 11.8 14.4 17.1 (number in millions);;Bone is comprised of 2 components: 40% organic collagenous 60% inorganic (mineral) matrix providing tensile mostly in the form of strength. Calcium hydroxyapetite providing compressive strength. ;Metabolic bone disease categorized by histology : Osteoporosis Osteomalacia Decrease in matrix Bone matrix intact and mineral. reduced mineral. Osteoporosis defintion by NIH Consensus Conference, 2000: Skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. Bone strength= Bone density + Bone quality1 ;Regulation of bone remodeling.;Local growth factors that regulate bone formation;PTH-related protein: produced by bone and cartilage cells has developmental and local regulatory function.13,14 Its secretion by lactating mammary glands may play a role in the increased rate of bone resorption and rapid bone loss that occurs in lactating women.15 Fibroblast growth factor: produced by bone and connective tissue. Regulated by PTH, prostaglandin