hif1α在实验性sah早期脑损伤中的调控及槲皮素作用分析-regulation of hi f1 α in experimental sah early brain damage and analysis of quercetin effect.docxVIP

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hif1α在实验性sah早期脑损伤中的调控及槲皮素作用分析-regulation of hi f1 α in experimental sah early brain damage and analysis of quercetin effect.docx

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hif1α在实验性sah早期脑损伤中的调控及槲皮素作用分析-regulation of hi f1 α in experimental sah early brain damage and analysis of quercetin effect

3.1SAH模型大鼠基底动脉面积及厚度的变化及槲皮素对其影响663.2SAH模型大鼠基底动脉eNOS蛋白表达变化及槲皮素对其影响673.3SAH模型大鼠血清eNOS浓度变化及槲皮素对其影响684讨论·································································································68第五部分槲皮素在实验性SAH模型对大鼠海马HIF-1?的调节作用研究··········711材料·································································································711.1动物···························································································711.2试剂···························································································711.3仪器···························································································712方法·································································································712.1动物分组·····················································································712.2大鼠蛛网膜下腔二次出血模型建立···················································722.3动物灌注及取材···········································································722.4免疫组织化学染色········································································722.5Westernblot测定732.6统计学分析··················································································743结果·································································································743.1SAH模型大鼠海马CA1区HIF-1?的形态表达变化及槲皮素对其影响···743.2SAH模型大鼠海马HIF-1?蛋白的表达变化及槲皮素对其影响744讨论·································································································75小结····································································································77参考文献····································································································78附录····································································································98研究成果····································································································99缩略语表缩略词英文全称中文全称ADAlzheimer’sdisease阿尔茨海默病ALSamyotrophiclateralsclerosis肌萎缩性脊髓侧索硬化症BAbasilarartery基底动脉BBBbloodb