不可切除大肠癌肝转移我学科综合治疗发展(附3例病例讨论)-development of comprehensive treatment of unresectable liver metastasis from colorectal cancer ( with discussion of 3 cases ).docxVIP

不可切除大肠癌肝转移我学科综合治疗发展(附3例病例讨论)-development of comprehensive treatment of unresectable liver metastasis from colorectal cancer ( with discussion of 3 cases ).docx

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不可切除大肠癌肝转移我学科综合治疗发展(附3例病例讨论)-development of comprehensive treatment of unresectable liver metastasis from colorectal cancer ( with discussion of 3 cases )

therapy of argon-helium knife and percutaneous ethanol injection are the most commonly used.In sum, different patients or at different stages of the same patient, different comprehensive treatment strategies can be used. In them multidisciplinary treatments above can also be alone or combined. For example, to patients who can not tolerate high intensity chemotherapy, the strategy of single-agent chemotherapy ± molecular targeted therapy can be used; to patients who can tolerate high intensity chemotherapy, the strategy of combined chemotherapy ± molecular targeted therapy can be used; to patients who can tolerate high intensity chemotherapy with the distribution of diffuse liver metastases or richer blood supply, the strategy of transcatheter arterial chemoembolization ± molecular targeted therapy can be used; and to patients who can tolerate high intensity chemotherapy with the distribution of non-diffuse liver metastases, the strategy of minimally invasive interventional treatment ± chemotherapy ± molecular targeted therapy can be uesd usually.Key words:Multidisciplinary synthetic therapy;Minimally invasive therapy; Colorectal liver metastasis缩略词表英文缩写英文全称中文译名ASCOAmerican Society of Clinical Oncology美国临床肿瘤学会BSCBest surpportive care最佳支持治疗CRCColorectal cancer大肠癌CRLMColorectal liver metastasis大肠癌肝转移EGFREpidermal growth factor receptor表皮生长因子受体 FDAFood and Drug Administration美国食品药物管理局 mCRCMetastatic colorectal cancer转移性大肠癌NCCNNational Comprehensive Cancer Network国立综合癌症网络OSOverall survival总生存期PEIPercutaneous Ethanol Injection无水酒精瘤内注射PFSProgression-free survival无进展生存期PRPartial response部分缓解RFARadiofrequency ablation射频消融RRResponse rate有效率;反应率SDStable disease疾病稳定TACETranscatheterarterial chemoembolizationVEGFVascular endothelial growth factor receptor经导管化疗栓塞术血管内皮生长因子受体目录中文摘要 I英文摘要 II缩略词表 IV目录 V第 1 章 前言 1第 2 章 大肠癌肝转移不可手术切除的基本共识 2第 3 章 多学科治疗方法及其进展 33.1 化学治疗 33.1.1 常用化疗药物 33.1.2 常用化疗方案及其评价 43.2 分子靶向治疗 53.2.1 西妥昔单抗治疗 53.2.2 贝伐单抗治疗 63.3 微创介入治疗 73.3.1 肝动脉化疗栓塞治疗 73.3

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