分娩发动前后孕妇蜕膜及外周血中nk nkt细胞生物学特性的分析-biological characteristics of nk nkt cells in decidua and peripheral blood of pregnant women before and after delivery.docxVIP

安徽医科大学硕士学位论文 安徽医科大学硕士学位论文 - - 6 - The study of biological characteristic of NK cells and NK cells before and after the onset of normal labour Background： Abstract In normal pregnancy, there were immunotolerance between mothers immune system with paternal fetal , though many factors play a part in it. Recent years, many study display that NK cells and NKT cells play an impotant roles in fetal-maternal interface, they produce large amounts of both Th1 and Th2 cytokines, and regulate immune responses by modulating T helper type 1/type 2 (Th1/Th2) balance. In pregnancy, hemiallogeneic fetal spared from attack by the maternal immune system. There were Th2-dominance by different mechanisms constitute a distinct immunologic microenvironment inside maternal-fetal interface to maintenance successful pregnancy. Recent study has concentrated on the role of immune balance with some disease of pregnancy(include recurrent spontaneous abortion, intrahepatic cholestasis of pregnancy, gestational hypertension, the onset of labour, et al) , and suggested that innate immune system including NK cells and NKT cells might play an important role in pregnancy progression. The mechanisms of onset of human parturition are very complicated, despite important advances in our understanding of the mechanism of human parturition, more study were concentrate on histology and immunology. Recent research on maternal-fetal interface has been proposed，the main content is composed of maternal uterus deciduas and fetal trophoblast，γδT cells、NK cells、NKT cells、CTL and secreted cytokine are composed of special immunological microenvironment on at the maternal-fetal interface ， which is crucial for embryo implantation 、 gestational maintenance、disease of pregnancy and the onset of labour. Recent research on maternal-fetal interface has been proposed，the main content is composed of maternal uterus deciduas and fetal trophoblast，all kinds of cells and - - 7 - secreted cytokine are composed of spec