儿科学经典教学课件-9Hematopoies Anemia for 7yr.pptVIP

Contents―Blood System The development of the hematopoietic System Blood Cell Counts The introduction of Anemia Iron deficiency anemia Development of the Hematopoietic System (造血系统的发育) Dr.Jie Yu, MD. Professor The department of Pediatric, Hematology/Oncology, Skeleton Bone marrow Liver Spleen Blood vessel In the embryo and fetus, constant changes characterize all phases of hematopoiesis. Hematopoiesis 造血 Hematopoietic 造血的 Contents Aims Hematopoietic organ Hematopoietic blood cells Hematopoiesis 造血 Hematopoietic 造血的 Development of Hematopoietic Organs Fetal hematopoiesis Mesoblastic Hematopoiesis （中胚层) Hepatic Hematopoiesis (肝脏） Myeloid Hematopoiesis （骨髓） Hematopoiesis after birth Table 1. Fetal Hematopoiesis Trimester 三个月，学期 Development of Hematopoietic Organs Fetal hematopoiesis Hematopoiesis after birth Bone marrow hematopoiesis Extrmedullary（骨髓外） hematopoiesis Development of Hematopoietic Organs Hematopoiesis after birth Bone marrow hematopoiesis All blood cells are produced in the marrow after 2nd trimester Newborn and early infancy: red marrow 5-7yr : yellow marrow Extramedullary hematopoiesis The site for bone marrow aspiration: Newborn and early infancy — tibia(胫骨) After the infancy period — posterior superior iliac spine（髂后上脊） Development of Hematopoietic Organs Hematopoiesis after birth Bone marrow hematopoiesis Extramedullary hematopoiesis (骨髓外造血) In disease status: red cell production hematopoietic tissue. blood production expands to replace fatty marrow. blood cells production extends to extramedullary sites ( liver and spleen). Development of Hematopoietic Organs Hematopoiesis after birth Extramedullary hematopoiesis QA: In infants and children, hemolytic disease results in a relatively greater enlargement of the liver and spleen than in adults ? Development of the Hematopoietic Blood Cells Pluripotent Stem Cells: which are capable of both self-renewal an