尿TGF-β1、Ⅳ型胶原与早期糖尿病肾损害及科素亚干预作用.docVIP

尿TGF-β1、Ⅳ型胶原与早期糖尿病肾损害及科素亚干预作用 　　【摘要】 目的 探讨尿中转化生长因子β1(TGF-β1)、Ⅳ型胶原(T4C)与早期糖尿病肾病(EDN)肾脏损害关系及科素亚的干预作用。方法 检测113例2型糖尿病患者(EDN组68例、未合并肾病组-T2DM组45例)尿中TGF-β1、T4C、尿白蛋白排泄率(UAER)，比较EDN与T2DM组TGF-β1、T4C水平差异，并就EDN组科素亚干预前后TGF-β1、T4C、UAER水平差异及三者之间相关性进行统计分析。结果 EDN组TGF-β1、T4C水平明显高于T2DM组；科素亚干预前后分析表明，EDN组尿中TGF-β1、T4C与UAER之间具有较高正相关性(P均0.05)。结论 EDN组尿中TGF-β1、T4CEDN肾脏损害有较密切关系，尿中TGF-β1、T4C水平可以作为EDN诊断和监控指标；科素亚对TGF-β1、T4C、UAER有一定干预作用。 　　【关键词】 转化生长因子β1；Ⅳ型胶原；尿白蛋白排泄率；糖尿病肾病 　　文章编号：1003-1383(2007)04-0364-02 　　中图分类号：R 587.1 　　文献标识码：A 　　 　　Correlation between urinary transforming growth factor beta1type Ⅳ collagen and the lesion of early diabetic nephropathy along with the intervene effect of Cozaar 　　CHEN Kuan-lin 　　(Jiangsu staff Medical University，Nanjing，Jiangsu，210029) 　　 　　【Abstract】 Objective To study the correlation between urinary transforming growth factor beta1(TGF-β1)，type Ⅳ collagen(T4C) and the lesion of early diabetic nephropathy(EDN)，and to research the intervene effect of Cozaar along with it.Methods 113 diabetic cases were divided into END group(68 cases) and T2DM group(45 cases) . The levels of urinary TGF-β1，T4C and urinanry albumin excreation rate(UAER) were detected and compared the TGF-β1、T4C level in the two groups.And detected the TGF-β1、T4C、 UAER level changing before and after applied cozaar in EDN group.Results The TGF-β1、T4C level in END group were obviouslyhigher than those inT2DM group .Statistic analysis indicating the high positively correlation between urinary TGF-β1， T4C and UAER，and there urinary level were decreased after intervene of cozaar.Conclusion the urinary TGF-β1， T4C are positively correlated with the lesion of EDN；and they can be taken as surveying indicators of EDN.Cozaar can affect the urinary TGF-β1、T4C、UAER level. 　　【Key words】 transforming growth factor beta1；type Ⅳ collagen；albumin excreation rate；diabetic nephropathy 　　 　　本研究先前的实验和相关结果表明[1，2]，糖尿病肾病(DN)患者血清转化生长因子β1(TGF-β1)水平升高；Ⅳ型胶原(T4C)作为肾小球系膜细胞外基质重要成分，尿和血中水平反应了DN时肾脏损害程度[3]。为探讨尿中TGF-