递增负荷运动引起运动性血红蛋白低下特点及机制.docVIP

递增负荷运动引起运动性血红蛋白低下特点及机制 　　摘 要： 目的：为探讨运动性血红蛋白低下时机体铁代谢、红细胞破坏与血红蛋白下降间的关 系，为运动性血红蛋白低下的发生机制及预防提供依据。方法：随机选取广州体育学院体育 教育系学生30人，男女各15人，进行起始负荷为60%最大心率强度，每周强度递增10%的跑步 运动，5 d/周，4周后测试受试者Hb、Ret、SF、Fer、sTfR和红细胞抗氧化指标MDA、SOD、C A T、GSH-px。结果：4周递增负荷跑步运动后受试者呈现运动性血红蛋白低下，血清铁蛋白持 续性下降，转铁蛋白受体呈下降趋势或不变，但血清铁无明显变化；红细胞抗氧化酶的含量 升高，脂质过氧化产物MDA呈持续增加趋势。结论：4周的递增负荷跑步运动中，红细胞自 由基的生成增加及红细胞抗氧化能力的相对降低引起的红细胞破坏增加可能是运动性血红蛋 白低下的发生原因，而不是由单纯缺铁所致。 　　关键???：递增负荷；跑步运动；运动性血红蛋白低下；铁代谢；红细胞破坏 ；抗氧化酶 　　中图分类号：G804.7 文献标识码：A 文章编 号：1007-3612(2011)05-0052-04 　　The Characteristic and Mechanism of Exercise?Induced Anemia dur ing Increasing Intensity Running 　　LIN Wen?tao，XU Guo?qin，WENG Xi?quan 　　(Provincial Key Laboratory of Exercise Biochemistry， GuangzhouSport University，Guangzhou 510500， Guangdong China) 　　Abstract: Purpose: To research the relationship among iron metabolism，red blood cell des truction and hemoglobin decreasing during exercise?induced anemia，which provid es a basis for the mechanism and prevention of exercise?induced anemia.Method : 30 students (male 15，female 15) were chose and taken increasing intensity run ning at 60%HRmax，increasing 10%HRmax every week.Four weeks later the blood Hb 、Ret、SF、Fer、sTfR，and MDA、SOD、CAT、GSH?px of RBC were measured.Results:After 4 weeks increasing intensity running，Hb decreases significantly as exerc ise?induced anemia， and serum ferritin declining sustained，transferrin recep tor，a downward trend or the same，but no significant change in serum iron; Thelevels of erythrocyte antioxidant enzymes were elevated，and lipid peroxidatio n MDA showed a tend of increasing. Conclusion: During the four weeks increasingintensity running，the increased free radicals and the lowered antioxidant capa city of red blood cell maybe the main reasons of exercise?induced anemia，rath er than simply iron deficiency. 　　Key words: increasing intensity; running; exercise?induced anemia; ironmetabolism; red blood cell destruction; antioxidant enzymes 　　运动性贫血极大地影响运动员尤其是体能类项目运动员的运动能力发挥。虽然在运动训练过 程中发生实质性