静脉曲张出血预防性使用抗生素的临床意义-胃肠病学和肝病学杂志.DOC

肝硬化消化道出血院内感染的危险因素及其临床意义 黄紫庆，袁桂林，冷佳源，沈 薇 重庆医科大学附属第二医院消化内科，重庆 400010 【摘要】 目的 探讨肝硬化消化道出血患者院内感染的危险因素及其临床意义。方法 收集重庆医科大学附属第二医院2009年10月--2014年1月肝硬化并发消化道出血患者的临床资料，分析院内感染、再出血的高危因素，预防性使用抗生素对院内感染及再出血的影响。R575.2；R573.2 文献标识码：A 文章编号： 收稿日期：2014-08-25 Risk factors of nosocomial infection of liver cirrhosis patients with gastrointestinal bleeding and its clinical significance HUANG Ziqing1, YUAN Guilin, LENG Jiayuan, SHEN Wei2 Department of Gastroenterology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China 【】Objective To investigate risk factors of nosocomial infection of liver cirrhosis patients with gastrointestinal bleeding and analysis its clinical significance. Methods Collect clinical data of liver cirrhosis inpatients with gastrointestinal bleeding from Oct. 2007 to Jan. 2014, to analysis the risk factors of nosocomial infection and rebleeding，and to discuss the affects of prophylactic antibiotics to the rates of nosocomial infection and rebleeding. Results (1) The nosocomial infection rate of liver cirrhosis patients with gastrointestinal bleeding was 20.8%, the nosocomial infection rate of liver cirrhosis patients without gastrointestinal bleeding was 5.4% (P0.01). (2) Infection group and non-infection group had obvious differences in WBC count, Child-Pugh score, bleeding way, prophylactic antibiotics, nosocomial rebleeding (P0.05). (3) Compare rebleeding group with non-rebleeding group, two groups had obvious differences in age, WBC count, high Child-Pugh score. (4) The nonsocial infection rate of prophylactic antibiotics group and non-prophylactic antibiotics group were 11.3%, 27.8%, had significant difference (P0.01), their rebleeding rate were 13.0%, 12.0%, had insignificant difference (P0.05). (5) Prophylactic antibiotics could dramatically decrease the nonsocial infection rate of haematemesis patient, while had no significant difference in melena patient. The infection rate of haematemesis patients in prophyl